Seki H, Mitsuhashi N, Mizuno M, Satoh K
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Feb;43(2):152-6.
The concentrations of endothelin (ET) in maternal vein (MV), umbilical vein (UV) and artery (UA) of normal pregnancy (N) and severe pregnancy-induced hypertension (sPIH) were measured to investigate the significance of ET in the maternal and feto-placental circulation of normal pregnancy and PIH. 1) The concentrations of ET (pg/ml blood: mean +/- S.E.M.) in MV of a normal non-pregnant group, 1st, 2nd and 3rd trimester of N were 1.00 +/- 0.19 (n = 2), 0.55 +/- 0.16 (n = 4), 0.45 +/- 0.14 (n = 4) and 0.89 +/- 0.09 (n = 10), respectively. The concentration of ET in MV of 3rd trimester of sPIH was 2.76 +/- 1.21 (n = 7), and significantly (p less than 0.05) higher than in MV of 3rd trimester of N. 2) The concentrations of ET in UV and UA of N and UV of sPIH were 1.53 +/- 0.05, 1.29 +/- 0.06, 2.12 +/- 0.46, respectively. The concentrations of ET in UV and UA of N were significantly (p less than 0.01) higher than in MV of N. 3) The concentrations of ET in MV of N and sPIH correlated significantly (p less than 0.05) with diastolic blood pressure of N (r = 0.53). It was concluded that the synthesis of ET during pregnancy was suppressed until the 2nd trimester, and that the increased ET in MV of sPIH might be one of the factors that caused the pathogenesis of PIH. And the high concentration of ET in UV and UA was supposed to operate play a role in feto-placental circulation.
测量正常妊娠（N）和重度妊娠高血压综合征（sPIH）孕妇母血静脉（MV）、脐静脉（UV）和脐动脉（UA）中内皮素（ET）的浓度，以探讨ET在正常妊娠和妊娠高血压综合征母婴及胎儿 - 胎盘循环中的意义。1）正常未孕组、正常妊娠第1、2、3孕期母血静脉中ET的浓度（pg/ml血：均值±标准误）分别为1.00±0.19（n = 2）、0.55±0.16（n = 4）、0.45±0.14（n = 4）和0.89±0.09（n = 10）。重度妊娠高血压综合征第3孕期母血静脉中ET的浓度为2.76±1.21（n = 7），显著高于（p＜0.05）正常妊娠第3孕期母血静脉中的浓度。2）正常妊娠脐静脉和脐动脉以及重度妊娠高血压综合征脐静脉中ET的浓度分别为1.53±0.05、1.29±0.06、2.12±0.46。正常妊娠脐静脉和脐动脉中ET的浓度显著高于（p＜0.01）正常妊娠母血静脉中的浓度。3）正常妊娠和重度妊娠高血压综合征母血静脉中ET的浓度与正常妊娠舒张压显著相关（p＜0.05）（r = 0.53）。结论为孕期ET的合成在孕中期之前受到抑制，重度妊娠高血压综合征母血静脉中ET升高可能是导致妊娠高血压综合征发病的因素之一。脐静脉和脐动脉中ET的高浓度可能在胎儿 - 胎盘循环中起作用。
