妊娠高血压综合征患者血浆内皮素水平及其与心钠素的相关性

[Plasma endothelin level in patients with pregnancy induced hypertension and its correlation with atrial natriuretic peptide].

作者信息

Zhang S H, Yang M G, Qiu X H

机构信息

Tangdu Hospital, Fourth Military Medical University, Xi'an.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 1994 Nov;29(11):645-7, 697.

PMID:7712881

Abstract

Plasma levels of endothelin (ET) and atrial natriuretic peptide (ANP) were measured in 32 normal pregnant women and 26 patients with pregnancy induced hypertension (PIH). The correlation between ET and ANP were examined. This study indicated that the levels of ET and ANP in hypertensive pregnancy were higher than those of the normal pregnancy (P < 0.01). There was no correlation between ET and ANP in normal pregnancy (r = 0.18, P > 0.05), but significant inverse correlation in the patient with PIH (r = -0.57, P < 0.05). There findings suggested that ET may play an important role in the pathogenesis of PIH. An imbalance of increased amount of ET relative to deficient ANP may lead to PIH.

摘要

对32名正常孕妇和26名妊娠高血压综合征（PIH）患者测定了血浆内皮素（ET）和心钠素（ANP）水平，并检测了ET与ANP之间的相关性。本研究表明，高血压妊娠患者的ET和ANP水平高于正常妊娠患者（P<0.01）。正常妊娠时ET与ANP无相关性（r=0.18，P>0.05），但PIH患者中二者呈显著负相关（r=-0.57，P<0.05）。这些发现提示ET可能在PIH的发病机制中起重要作用。ET量增加而ANP不足的失衡可能导致PIH。