• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

FOXP3 和 GARP（LRRC32）：主人和他的仆人。

FOXP3 and GARP (LRRC32): the master and its minion.

机构信息

Institute for Microbiology, Immunology and Hygiene, Städtisches Klinikum Braunschweig gGmbH, Braunschweig, Germany.

出版信息

Biol Direct. 2010 Feb 5;5:8. doi: 10.1186/1745-6150-5-8.

DOI:10.1186/1745-6150-5-8
PMID:20137067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2825496/
Abstract

The transcription factor FOXP3 is essential for the development and function of CD4+CD25hiFOXP3+ regulatory T (T(reg)) cells, but also expressed in activated human helper T cells without acquisition of a regulatory phenotype. This comment focuses on glycoprotein-A repetitions predominant (GARP or LRRC32) recently identified as specific marker of activated human T(reg) cells, which may provide the missing link toward a better molecular definition of the regulatory phenotype.

摘要

转录因子 FOXP3 对于 CD4+CD25hiFOXP3+调节性 T（Treg）细胞的发育和功能至关重要，但也在没有获得调节表型的活化人类辅助性 T 细胞中表达。这篇评论重点介绍了最近被鉴定为活化人类 Treg 细胞特异性标志物的糖蛋白-A 重复为主（GARP 或 LRRC32），这可能为调节表型的更好分子定义提供了缺失的环节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f811/2825496/0056a8fafb5c/1745-6150-5-8-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f811/2825496/0056a8fafb5c/1745-6150-5-8-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f811/2825496/0056a8fafb5c/1745-6150-5-8-1.jpg

相似文献

1
FOXP3 and GARP (LRRC32): the master and its minion.FOXP3 和 GARP（LRRC32）：主人和他的仆人。
Biol Direct. 2010 Feb 5;5:8. doi: 10.1186/1745-6150-5-8.
2
FOXP3: required but not sufficient. the role of GARP (LRRC32) as a safeguard of the regulatory phenotype.FOXP3：必需但非充分条件。GARP（LRRC32）作为调节表型的保护者的作用。
Curr Mol Med. 2010 Aug;10(6):533-9. doi: 10.2174/1566524011009060533.
3
GARP: a key receptor controlling FOXP3 in human regulatory T cells.GARP：调控人调节性 T 细胞中 FOXP3 的关键受体。
J Cell Mol Med. 2009 Sep;13(9B):3343-57. doi: 10.1111/j.1582-4934.2009.00782.x. Epub 2009 May 13.
4
Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.GARP的表达可选择性地识别活化的人类FOXP3 +调节性T细胞。
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13439-44. doi: 10.1073/pnas.0901965106. Epub 2009 Jul 28.
5
Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.鉴定一种调节性T细胞特异性细胞表面分子，该分子介导抑制性信号并诱导Foxp3表达。
PLoS One. 2008 Jul 16;3(7):e2705. doi: 10.1371/journal.pone.0002705.
6
CD4  CD25  GARP regulatory T cells display a compromised suppressive function in patients with dilated cardiomyopathy.在扩张型心肌病患者中，CD4 CD25 GARP调节性T细胞表现出受损的抑制功能。
Immunology. 2017 Jul;151(3):291-303. doi: 10.1111/imm.12728. Epub 2017 Mar 29.
7
GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.GARP-TGF-β 复合物负调控体内调节性 T 细胞的发育和外周 CD4+T 细胞的维持。
J Immunol. 2013 May 15;190(10):5057-64. doi: 10.4049/jimmunol.1300065. Epub 2013 Apr 10.
8
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.GARP（富含亮氨酸重复序列蛋白32）对于血小板和活化的FOXP3 +调节性T细胞上潜伏性转化生长因子-β的表面表达至关重要。
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13445-50. doi: 10.1073/pnas.0901944106. Epub 2009 Jul 27.
9
GARP: a surface molecule of regulatory T cells that is involved in the regulatory function and TGF-β releasing.GARP：一种调节性T细胞的表面分子，参与调节功能和转化生长因子-β的释放。
Oncotarget. 2016 Jul 5;7(27):42826-42836. doi: 10.18632/oncotarget.8753.
10
The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance.调节性T细胞上的GARP/潜伏性转化生长因子-β1复合物在口服耐受过程中调节外周来源调节性T细胞的诱导。
Eur J Immunol. 2016 Jun;46(6):1480-9. doi: 10.1002/eji.201546204. Epub 2016 Apr 23.

引用本文的文献

1
A Novel TGF-β Risk Score Predicts the Clinical Outcomes and Tumour Microenvironment Phenotypes in Bladder Cancer.一种新型 TGF-β 风险评分可预测膀胱癌的临床结局和肿瘤微环境表型。
Front Immunol. 2021 Dec 17;12:791924. doi: 10.3389/fimmu.2021.791924. eCollection 2021.
2
Altered Hippocampal Epigenetic Regulation Underlying Reduced Cognitive Development in Response to Early Life Environmental Insults.早期生活环境刺激导致认知发育迟缓的海马表观遗传调控改变。
Genes (Basel). 2020 Feb 4;11(2):162. doi: 10.3390/genes11020162.
3
Influence of Platelet Lysate on 2D and 3D Amniotic Mesenchymal Stem Cell Cultures.

本文引用的文献

1
Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.支柱文章：转录因子Foxp3对调节性T细胞发育的控制。《科学》2003年。299卷：1057 - 1061页。
J Immunol. 2017 Feb 1;198(3):981-985.
2
Perspectives on Regulatory T Cell Therapies.调节性T细胞疗法的前景
Transfus Med Hemother. 2009;36(5):302-308. doi: 10.1159/000235929. Epub 2009 Sep 10.
3
FOXP3: required but not sufficient. the role of GARP (LRRC32) as a safeguard of the regulatory phenotype.FOXP3：必需但非充分条件。GARP（LRRC32）作为调节表型的保护者的作用。
血小板裂解物对二维和三维羊膜间充质干细胞培养的影响。
Front Bioeng Biotechnol. 2019 Nov 15;7:338. doi: 10.3389/fbioe.2019.00338. eCollection 2019.
4
Increased Expression of GARP in Papillary Thyroid Carcinoma.甲状腺乳头状癌中 GARP 的表达增加。
Endocr Pathol. 2019 Mar;30(1):1-7. doi: 10.1007/s12022-018-9557-0.
5
Immunophenotype and Transcriptome Profile of Patients With Multiple Sclerosis Treated With Fingolimod: Setting Up a Model for Prediction of Response in a 2-Year Translational Study.用芬戈莫德治疗的多发性硬化症患者的免疫表型和转录组概况：在一项为期两年的转化研究中建立反应预测模型。
Front Immunol. 2018 Jul 25;9:1693. doi: 10.3389/fimmu.2018.01693. eCollection 2018.
6
A genetics-based approach confirms immune associations with life history across multiple populations of an aquatic vertebrate (Gasterosteus aculeatus).基于遗传学的方法证实了水生脊椎动物（棘胸鱼）多个种群的生活史与免疫系统之间的关联。
Mol Ecol. 2018 Aug;27(15):3174-3191. doi: 10.1111/mec.14772. Epub 2018 Jul 9.
7
Eda haplotypes in three-spined stickleback are associated with variation in immune gene expression.三刺鱼中的 Eda 单倍型与免疫基因表达的变化有关。
Sci Rep. 2017 Feb 14;7:42677. doi: 10.1038/srep42677.
8
Decreased FOXP3+ and GARP+ Tregs to neoadjuvant chemotherapy associated with favorable prognosis in advanced gastric cancer.晚期胃癌中，新辅助化疗后FOXP3+和GARP+调节性T细胞减少与预后良好相关。
Onco Targets Ther. 2016 Jun 14;9:3525-33. doi: 10.2147/OTT.S101884. eCollection 2016.
9
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.分子伴侣gp96/grp94的客户与致癌作用
Curr Top Med Chem. 2016;16(25):2765-78. doi: 10.2174/1568026616666160413141613.
10
Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients.将FoxP3和Helios与GARP/LAP标志物相结合，能够识别癌症患者中扩增的调节性T细胞亚群。
Oncotarget. 2016 Mar 22;7(12):14083-94. doi: 10.18632/oncotarget.7334.
Curr Mol Med. 2010 Aug;10(6):533-9. doi: 10.2174/1566524011009060533.
4
Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.膜蛋白 GARP 是激活的人 Treg 表面上潜伏 TGF-β的受体。
Eur J Immunol. 2009 Dec;39(12):3315-22. doi: 10.1002/eji.200939684.
5
Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells.GARP的表达可选择性地识别活化的人类FOXP3 +调节性T细胞。
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13439-44. doi: 10.1073/pnas.0901965106. Epub 2009 Jul 28.
6
Foxp3 regulates megakaryopoiesis and platelet function.Foxp3 调节巨核细胞生成和血小板功能。
Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1874-82. doi: 10.1161/ATVBAHA.109.193805. Epub 2009 Aug 6.
7
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.GARP（富含亮氨酸重复序列蛋白32）对于血小板和活化的FOXP3 +调节性T细胞上潜伏性转化生长因子-β的表面表达至关重要。
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13445-50. doi: 10.1073/pnas.0901944106. Epub 2009 Jul 27.
8
Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity.T细胞中谱系特异性DNA甲基化与组蛋白甲基化及增强子活性相关。
Genome Res. 2009 Jul;19(7):1165-74. doi: 10.1101/gr.091470.109. Epub 2009 Jun 3.
9
GARP: a key receptor controlling FOXP3 in human regulatory T cells.GARP：调控人调节性 T 细胞中 FOXP3 的关键受体。
J Cell Mol Med. 2009 Sep;13(9B):3343-57. doi: 10.1111/j.1582-4934.2009.00782.x. Epub 2009 May 13.
10
The CD4(+) T-cell response of melanoma patients to a MAGE-A3 peptide vaccine involves potential regulatory T cells.黑色素瘤患者对MAGE - A3肽疫苗的CD4(+) T细胞反应涉及潜在的调节性T细胞。
Cancer Res. 2009 May 15;69(10):4335-45. doi: 10.1158/0008-5472.CAN-08-3726. Epub 2009 May 12.