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2
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本文引用的文献

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Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.支柱文章：转录因子Foxp3对调节性T细胞发育的控制。《科学》2003年。299卷：1057 - 1061页。
J Immunol. 2017 Feb 1;198(3):981-985.
2
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.GARP（富含亮氨酸重复序列蛋白32）对于血小板和活化的FOXP3 +调节性T细胞上潜伏性转化生长因子-β的表面表达至关重要。
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3
Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity.T细胞中谱系特异性DNA甲基化与组蛋白甲基化及增强子活性相关。
Genome Res. 2009 Jul;19(7):1165-74. doi: 10.1101/gr.091470.109. Epub 2009 Jun 3.
4
Human T regulatory cell therapy: take a billion or so and call me in the morning.人类调节性T细胞疗法：先准备大约十亿个，明天早上再联系我。
Immunity. 2009 May;30(5):656-65. doi: 10.1016/j.immuni.2009.04.006.
5
GARP: a key receptor controlling FOXP3 in human regulatory T cells.GARP：调控人调节性 T 细胞中 FOXP3 的关键受体。
J Cell Mol Med. 2009 Sep;13(9B):3343-57. doi: 10.1111/j.1582-4934.2009.00782.x. Epub 2009 May 13.
6
The CD4(+) T-cell response of melanoma patients to a MAGE-A3 peptide vaccine involves potential regulatory T cells.黑色素瘤患者对MAGE - A3肽疫苗的CD4(+) T细胞反应涉及潜在的调节性T细胞。
Cancer Res. 2009 May 15;69(10):4335-45. doi: 10.1158/0008-5472.CAN-08-3726. Epub 2009 May 12.
7
Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures.潜伏相关肽（LAP）和白细胞介素-1受体I/II型（CD121a/CD121b）在活化的人FOXP3 +调节性T细胞上的选择性表达，使得它们能够从扩增培养物中纯化出来。
Blood. 2009 May 21;113(21):5125-33. doi: 10.1182/blood-2009-01-199950. Epub 2009 Mar 18.
8
Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells.FOXP3(+)调节性T细胞的治疗潜力及其与树突状细胞的相互作用。
Hum Immunol. 2009 May;70(5):294-9. doi: 10.1016/j.humimm.2009.02.007. Epub 2009 Feb 21.
9
Comparison of stable human Treg and Th clones by transcriptional profiling.通过转录谱分析比较稳定的人调节性T细胞和辅助性T细胞克隆
Eur J Immunol. 2009 Mar;39(3):869-82. doi: 10.1002/eji.200838807.
10
Production Assistance for Cellular Therapies (PACT): four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in cell and tissue therapies.细胞疗法生产援助项目（PACT）：来自美国国立心肺血液研究所（NHLBI）细胞与组织疗法合同研究项目的四年经验。
Transfusion. 2009 Apr;49(4):786-96. doi: 10.1111/j.1537-2995.2008.02027.x. Epub 2008 Dec 23.

调节性T细胞疗法的前景

Perspectives on Regulatory T Cell Therapies.

作者信息

Probst-Kepper Michael, Kröger Andrea, Garritsen Henk S P, Buer Jan

机构信息

Institut für Mikrobiologie, Immunologie und Krankenhaushygiene, Braunschweig, Germany.

出版信息

Transfus Med Hemother. 2009;36(5):302-308. doi: 10.1159/000235929. Epub 2009 Sep 10.

DOI:10.1159/000235929
PMID:21076548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2969127/
Abstract

Adoptive transfer in animal models clearly indicate an essential role of CD4+ CD25+ FOXP3+ regulatory T (T(reg)) cells in prevention and treatment of autoimmune and graft-versus-host disease. Thus, T(reg) cell therapies and development of drugs that specifically enhance T(reg) cell function and development represent promising tools to establish dominant tolerance. So far, lack of specific markers to differentiate human T(reg) cells from activated CD4+ CD25+ effector T cells, which also express FOXP3 at different levels, hampered such an approach. Recent identification of the orphan receptor glycoprotein-A repetitions predominant (GARP or LRRC32) as T(reg) cell-specific key molecule that dominantly controls FOXP3 via a positive feedback loop opens up new perspectives for molecular and cellular therapies. This brief review focuses on the role of GARP as a safeguard of a complex regulatory network of human T(reg) cells and its implications for regulatory T cell therapies in autoimmunity and graft-versus-host disease.

摘要

动物模型中的过继转移清楚地表明，CD4+ CD25+ FOXP3+调节性T（T(reg)）细胞在自身免疫性疾病以及移植物抗宿主病的预防和治疗中发挥着重要作用。因此，T(reg)细胞疗法以及开发能特异性增强T(reg)细胞功能和发育的药物是建立显性耐受的有前景的工具。到目前为止，由于缺乏能将人类T(reg)细胞与活化的CD4+ CD25+效应T细胞区分开来的特异性标志物（这些效应T细胞也在不同水平表达FOXP3），阻碍了这种方法的应用。最近发现孤儿受体糖蛋白A重复序列优势分子（GARP或LRRC32）作为T(reg)细胞特异性关键分子，通过正反馈回路主导性地控制FOXP3，这为分子和细胞疗法开辟了新的前景。这篇简短的综述聚焦于GARP作为人类T(reg)细胞复杂调节网络的一种保障所发挥的作用及其对自身免疫性疾病和移植物抗宿主病中调节性T细胞疗法的意义。