Chen Xiao-ping, Jin Jian-long, Li Chuan-wu, Wang Fei-shi
College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Sep;27(9):557-9.
To observe the effects of low concentration of organophosphate pesticide chlorpyrifos (CPF) prenatal exposure on generation mouse brain development.
5 mg/kg CPF was administered daily on gestation days (GD) 7.5 - 11.5. On postnatal day (PD) 35, quantitative morphologic examines were measured in CA1, CA3, dentate gyrus regions of the hippocampus and somatosensory cortex.
After CPF prenatal exposure, selective morphology impairments were observed, showing 22.37%, 25.66% thinning of the CA1 and CA3 layers, 24.14% enlargement of the dentate guys and 81.77% to 74.61% decreasing of the ratio of neuron/glial of the somatosensory cortex.
There maybe slight morphological changes after prenatal low concentration pesticide exposure even without obviously systemic toxicity.
观察低浓度有机磷农药毒死蜱（CPF）孕期暴露对子代小鼠脑发育的影响。
在妊娠第7.5至11.5天，每日给予5mg/kg CPF。在出生后第35天，对海马体的CA1、CA3、齿状回区域以及体感皮层进行定量形态学检测。
CPF孕期暴露后，观察到选择性形态学损伤，表现为CA1和CA3层变薄22.37%、25.66%，齿状回增大24.14%，体感皮层神经元/胶质细胞比例降低81.77%至74.61%。
孕期低浓度农药暴露后可能存在轻微形态学变化，即使没有明显的全身毒性。
