College of Biological and Environmental Engineering, Zhejiang University of Technology, 18 Chao-Wang Road, Hangzhou 310032, China.
J Appl Toxicol. 2011 May;31(4):355-9. doi: 10.1002/jat.1598. Epub 2010 Nov 19.
Developmental exposure to chlorpyrifos (CPF) induces abnormalities in neurotransmission. In the present study, we evaluated the dopamine reaction patterns in brain regions after CPF exposure during different prenatal periods. Animals were exposed on gestational days (GD) 7.5-11.5 or 13-17 and assessed at GD17, and at postnatal days (PN) 14 and 60. CPF exposure during GD7.5-11.5 elicited a decrease in dopamine content at each measurement stages, with more changes in the hippocampus than in the cerebral cortex. In contrast, CPF exposure in GD13-17 elicited a decrease in dopamine content at PN14 and PN60, with more changes in the cerebral cortex than in the hippocampus. These results suggest that the two key brain regions involved in learning and memory, the cerebral cortex and hippocampus, react differently to CPF exposure in different prenatal periods. The abnormalities did not recover long after cessation of CPF exposure and deficiencies persisted into pre-puberty and adulthood.
发育暴露于毒死蜱（CPF）会导致神经传递异常。在本研究中，我们评估了 CPF 在不同产前阶段暴露后大脑区域的多巴胺反应模式。动物在妊娠第 7.5-11.5 天或第 13-17 天接受暴露，并在妊娠第 17 天以及出生后第 14 天和第 60 天进行评估。在 GD7.5-11.5 天暴露于 CPF 会在每个测量阶段引起多巴胺含量下降，海马体的变化比大脑皮层更明显。相比之下，在 GD13-17 天暴露于 CPF 会在 PN14 和 PN60 时引起多巴胺含量下降，大脑皮层的变化比海马体更明显。这些结果表明，学习和记忆两个关键的大脑区域，大脑皮层和海马体，对不同产前阶段的 CPF 暴露反应不同。异常在 CPF 暴露停止后很长时间内没有恢复，并且缺陷持续到青春期前和成年期。
