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[肺动脉瓣狭窄患者经皮球囊肺动脉瓣成形术的结果]

[Outcome of percutaneous balloon pulmonary valvuloplasty for patients with pulmonary valve stenosis].

作者信息

Yu Zi-Xiang, Ma Yi-Tong, Yang Yi-Ning, Huang Ding, Ma Xiang, Fu Zhen-Yan, Liu Fen

机构信息

Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.

出版信息

Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Nov;37(11):1006-9.

Abstract

OBJECTIVE

To assess the effects of percutaneous balloon pulmonary valvuloplasty (PBPV) for patients with pulmonary valve stenosis (PS).

METHODS

From February 1996 to March 2003, 65 patients with isolated PS were diagnosed by echocardiography and received PBPV in our department, clinical data were analyzed in this study.

RESULTS

Age of 65 patients ranged from 1 to 48 years [mean (13.5 +/- 9.3) years]. The pulmonary transvalvular gradient (PTG) was (86.4 +/- 33.6) mm Hg(1 mm Hg = 0.133 kPa) and the right ventricular systolic pressure was (107.5 +/- 36.5) mm Hg before PBPV. Single-balloon valvuloplasty was performed in 41 patients, double-balloon valvuloplasty in 6 patients and Inoue-balloon valvuloplasty in 18 patients. The ratio of balloon/valve ranged from 1.00 to 1.19 in 19 patients, from 1.20 to 1.39 in 42 patients, and greater than 1.40 in 4 patients. The procedure was classified as successful when the RV-PA gradient was < 36 mm Hg post procedure, 6 to 12 months follow up was finished after PBPV by catheterization or echocardiography in 25 patients. Immediate post procedure success rate was 81.5% (53/65). The lowest PTG immediately post procedure was seen in Inoue balloon group and balloon/valve ratio between 1.20 to 1.39 group. Post procedure, tricuspid valve regurgitation was evidenced in 2 patients, reactive right ventricular outflow tract stenosis was shown in 26 patients (13 from Inoue group) and pulmonary regurgitation was detected in 3 patients. The mean PTG was (35.7 +/- 23.9) mm Hg at follow-up. PTG gradually reduced to normal in 6 patients with post procedure PTG > or = 36 mm Hg. Right ventricular outflow tract stenosis was attenuated in all 11 followuped patients. There was no restenosis during follow-up.

CONCLUSION

Percutaneous balloon valvuloplasty was effective and safe for treating patients with pulmonary valve stenosis. Superior outcome was linked with balloon/valve ratio between 1.20 to 1.39 and Inoue balloon valvuloplasty in this cohort.

摘要

目的

评估经皮球囊肺动脉瓣成形术(PBPV)治疗肺动脉瓣狭窄(PS)患者的效果。

方法

1996年2月至2003年3月,65例孤立性PS患者经超声心动图诊断后在我科接受PBPV,分析其临床资料。

结果

65例患者年龄1至48岁[平均(13.5±9.3)岁]。PBPV术前肺动脉跨瓣压差(PTG)为(86.4±33.6)mmHg(1mmHg = 0.133kPa),右心室收缩压为(107.5±36.5)mmHg。41例行单球囊瓣膜成形术,6例行双球囊瓣膜成形术,18例行Inoue球囊瓣膜成形术。19例患者球囊/瓣膜比值为1.00至1.19,42例为1.20至1.39,4例大于1.40。术后右心室-肺动脉压差(RV-PA梯度)<36mmHg时手术被判定为成功,25例患者PBPV后通过心导管检查或超声心动图完成6至12个月随访。术后即刻成功率为81.5%(53/65)。术后即刻PTG最低值见于Inoue球囊组及球囊/瓣膜比值在1.20至1.39组。术后,2例出现三尖瓣反流,26例出现反应性右心室流出道狭窄(Inoue组13例),3例检测到肺动脉反流。随访时平均PTG为(35.7±23.9)mmHg。术后PTG≥36mmHg的6例患者PTG逐渐降至正常。11例随访患者右心室流出道狭窄均减轻。随访期间无再狭窄发生。

结论

经皮球囊瓣膜成形术治疗肺动脉瓣狭窄患者有效且安全。在该队列中,较好的结果与球囊/瓣膜比值在1.20至1.39及Inoue球囊瓣膜成形术相关。

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