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[儿童期经皮球囊扩张治疗瓣膜性肺动脉狭窄的中长期疗效]

[Intermediate and long-term outcome after percutaneous balloon dilatation of valvular pulmonary stenoses in childhood].

作者信息

Mahnert B, Paul T, Luhmer I, Kallfelz H C

机构信息

Abteilung Kinderheilkunde III, Medizinische Hochschule Hannover.

出版信息

Z Kardiol. 1996 Jul;85(7):482-8.

PMID:8928546
Abstract

Pulmonary balloon valvuloplasty was performed in 52 patients aged 7 days to 19 years (mean 5.5 years). Mean balloon/anulus ratio was 1.24. Mean right ventricular outflow tract (RVOT) systolic pressure gradient was 79.9 +/- 37.3 (x +/- SD) mm Hg before valvuloplasty and 37.2 +/- 29.6 mm Hg (p < 0.001) immediately after the procedure. 33 patients had residual RVOT-gradient < or = 36 (22 +/- 7) mm Hg, 19 patients had gradients > 36 (67.1 +/- 35.6) mm Hg. During intermediate follow-up (< 2 years) RVOT gradient assessed by catheterization or Doppler echocardiography improved without any additional intervention in 10/19 patients with RVOT gradient > 36 mm Hg early after valvuloplasty. 6/19 patients required additional reduction of RVOT gradient by repeated valvuloplasty (51 +/- 19 to 29 +/- 5 mm Hg; p < 0.01). 3/19 patients needed surgical resection of extremely thickened dysplastic valves. 49 patients had a mid- to long-term follow-up by echocardiography (mean 4.3, max. 9 years); the RVOT gradient decreased from 25.7 +/- 12.8 mm Hg during intermediate follow-up to 18.0 +/- 7.0 mm Hg during long-term follow-up. If pulmonary regurgitation was present after dilatation (n = 38), it was hemodynamically not significant and did not change during follow-up. Percutaneous balloon valvuloplasty was a safe and effective treatment for pulmonary valve stenosis in infancy and childhood. Long-term results confirm the value of this method.

摘要

对52例年龄在7天至19岁(平均5.5岁)的患者实施了肺动脉球囊瓣膜成形术。平均球囊/瓣环比率为1.24。瓣膜成形术前右心室流出道(RVOT)收缩压平均梯度为79.9±37.3(x±标准差)mmHg,术后即刻为37.2±29.6 mmHg(p<0.001)。33例患者RVOT残余梯度≤36(22±7)mmHg,19例患者梯度>36(67.1±35.6)mmHg。在中期随访(<2年)期间,10/19例瓣膜成形术后早期RVOT梯度>36 mmHg的患者,经心导管检查或多普勒超声心动图评估,RVOT梯度在未进行任何额外干预的情况下有所改善。6/19例患者需要通过重复瓣膜成形术进一步降低RVOT梯度(从51±19降至29±5 mmHg;p<0.01)。3/19例患者需要手术切除极度增厚的发育异常瓣膜。49例患者通过超声心动图进行了中长期随访(平均4.3年,最长9年);RVOT梯度从中期随访时的25.7±12.8 mmHg降至长期随访时的18.0±7.0 mmHg。如果扩张后存在肺动脉反流(n = 38),其血流动力学意义不大,且在随访期间未发生变化。经皮球囊瓣膜成形术是婴幼儿和儿童肺动脉瓣狭窄的一种安全有效的治疗方法。长期结果证实了该方法的价值。

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