Lu Yi-hua, Sun Le-xian, Yan Jian-hua, Li Quan, Wang Yan-jie, Zhuang Xun, Zhang Ze-feng, Fan Zhong-jie
School of Public Health, Nantong University, Nantong, China.
Zhonghua Yi Xue Za Zhi. 2009 Nov 3;89(40):2827-30.
To evaluate quality of life (QOL) of patients with different severity of coronary artery disease using Seattle angina questionnaire (SAQ).
A total of 513 hospitalized patients undergoing coronary angiography from December 2007 to December 2008 were included. QOL of these patients was measured with SAQ and their demographic and clinical data were collected. Patients were divided into 3 groups according to the severity of coronary artery disease by coronary angiography. And comparisons of traditional risk factors and QOL were made among these groups. Multiple linear regression analysis was conducted to identify the variables associated with QOL.
The scores of physical limitation were significantly different among 3 groups according to the severity of coronary artery disease by coronary angiography (80 +/- 16, 79 +/- 19 and 71 +/- 22, P < 0.01). Multiple linear regression analysis showed that physical limitation of the patients was affected by age (P < 0.01), gender (P < 0.01) and severity of coronary artery disease (P < 0.01). Angina stability was affected by the history of myocardial infarction (P = 0.03). Angina frequency was affected by the history of myocardial infarction (P = 0.01) and gender (P = 0.04). Treatment satisfaction was affected by the severity of coronary artery disease (P = 0.03) and disease perception by the history of DM (P = 0.03).
Age, gender, history of myocardial infarction, history of DM and severity of coronary artery disease are independent predictors of QOL in patients with coronary artery disease.
使用西雅图心绞痛问卷（SAQ）评估不同严重程度冠状动脉疾病患者的生活质量（QOL）。
纳入2007年12月至2008年12月期间共513例行冠状动脉造影的住院患者。用SAQ测量这些患者的生活质量，并收集其人口统计学和临床资料。根据冠状动脉造影显示的冠状动脉疾病严重程度将患者分为3组。对这些组之间的传统危险因素和生活质量进行比较。进行多元线性回归分析以确定与生活质量相关的变量。
根据冠状动脉造影显示的冠状动脉疾病严重程度，3组患者的身体限制得分有显著差异（80±16、79±19和71±22，P<0.01）。多元线性回归分析显示，患者的身体限制受年龄（P<0.01）、性别（P<0.01）和冠状动脉疾病严重程度（P<0.01）影响。心绞痛稳定性受心肌梗死病史影响（P=0.03）。心绞痛发作频率受心肌梗死病史（P=0.01）和性别影响（P=0.04）。治疗满意度受冠状动脉疾病严重程度（P=0.03）和糖尿病病史对疾病的认知影响（P=0.03）。
年龄、性别、心肌梗死病史、糖尿病病史和冠状动脉疾病严重程度是冠状动脉疾病患者生活质量的独立预测因素。
