Fan Zhong-jie, Lu Yi-hua, Sun Li-xian, Yan Jian-hua, Li Quan, Wang Yan-jie, Zhuang Xun, Zhang Ze-feng, Gu Dong-feng, Yang Yue-jin
Division of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2009 Dec 15;89(46):3244-8.
Using Kansas city cardiomyopathy questionnaire (KCCQ) to evaluate the quality of life (QOL) of the patients with chronic heart failure.
A total of 271 hospitalized patients with heart failure symptoms in cardiology department, Peking Union Medical College Hospital, who undergone coronary angiography from December 2007 to December 2008, were included in this study. QOL of the subjects was measured, and their demographic and clinical data were collected. Patients were divided into 2 groups according to heart function and they were compared by QOL.Multiple linear regression analysis was conducted to identify the variables associated with the quality of life.
KCCQ physical limitation scores of the patients of left ventricular elective fraction (LVEF) < 50% (n = 50) and LVEF > or = 50% (n = 221) were (66 +/- 22) points and (73 +/- 22) points (P < 0.05). In the patients of NYHA I/II (n = 227) vs NYHA III/IV (n = 44), KCCQ scores of physical limitation, symptoms and QOL were (74 +/- 20) vs (60 +/- 27) points, (62 +/- 22) vs (49 +/- 25) points and (61 +/- 16) vs (53 +/- 18) points (all P < 0.05). In the patients of heart failure grade A/B (n = 197) vs grade C/D (n = 74), KCCQ scores of physical limitation, symptoms and QOL were (75 +/- 19) vs (61 +/- 26) points, (63 +/- 22) vs (52 +/- 24) points, (61 +/- 16) vs (56 +/- 18) points (all P < 0.05). Multiple linear regression analysis of QOL KCCQ showed that, age, NYHA cardiac function classification, gender and Judkins score were the risk factors of patients' physical limitation (P < 0.01); gender and stages of heart failure were the risk factors of patients'symptoms (P < 0.01); gender was the risk factors of patients'social function (P < 0.01).
The patients with poor cardiac function have a poor QOL. KCCQ is more sensitive for the evaluation of heart function. Age, NYHA, gender, Judkins score and stages of heart failure can change QOL for the patients with chronic heart failure.
采用堪萨斯城心肌病问卷（KCCQ）评估慢性心力衰竭患者的生活质量（QOL）。
纳入2007年12月至2008年12月在北京协和医院心内科住院的271例有心力衰竭症状且接受冠状动脉造影的患者。测量受试者的生活质量，并收集其人口统计学和临床资料。根据心功能将患者分为2组，并比较其生活质量。进行多元线性回归分析以确定与生活质量相关的变量。
左心室射血分数（LVEF）<50%（n = 50）和LVEF≥50%（n = 221）患者的KCCQ身体限制评分分别为（66±22）分和（73±22）分（P<0.05）。纽约心脏协会（NYHA）心功能I/II级（n = 227）与NYHA III/IV级（n = 44）患者相比，KCCQ身体限制、症状和生活质量评分分别为（74±20）分对（60±27）分、（62±22）分对（49±25）分和（61±16）分对（53±18）分（均P<0.05）。心力衰竭A/B级（n = 197）与C/D级（n = 74）患者相比，KCCQ身体限制、症状和生活质量评分分别为（75±19）分对（61±26）分、（63±22）分对（52±24）分、（61±16）分对（56±18）分（均P<0.05）。KCCQ生活质量的多元线性回归分析显示，年龄、NYHA心功能分级、性别和Judkins评分是患者身体限制的危险因素（P<0.01）；性别和心力衰竭分期是患者症状的危险因素（P<0.01）；性别是患者社会功能的危险因素（P<0.01）。
心功能差的患者生活质量差。KCCQ对心功能评估更敏感。年龄、NYHA分级、性别、Judkins评分和心力衰竭分期可改变慢性心力衰竭患者的生活质量。
