[有杀人行为和无杀人行为的精神分裂症患者的感觉门控P50]

Wang Hong-xing, Zhen Wen-feng, Ma Xin, Wang Yu-ping, Tian Jin-hua, Dou Qin-sheng, Zhao He-xin

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Zhonghua Yi Xue Za Zhi. 2009 Oct 13;89(37):2616-20.

OBJECTIVE

To investigate the change of sensory gating P50 in schizophrenic patients with and without homicide.

METHODS

The auditory evoked potentials P50 were recorded from 26 schizophrenic patients with homicide (Sch group), 27 schizophrenic patients without homicide (non-Sch group) and 32 normal controls (NC) using conditioning/testing paradigm presented with auditory double click stimuli by EGI 256 dense array. And the same time, their clinical symptoms were evaluated by positive and negative symptom scale (PANSS).

RESULTS

(1) Compared with NC, two Sch groups showed no significant difference in amplitude and latency of S1-P50 [amplitude: NC, Sch group, non-Sch group at Fz: (2.4 + or - 1.6) microV, (2.5 + or - 1.5) microV, (3.4 + or - 2.7) microV; latency: NC, Sch group, non-Sch group at Fz: (68 + or - 19) ms, (67 + or - 20) ms, (61 + or - 19) ms; respectively], but a higher amplitude and delayed latency of S2-P50 [amplitude: NC, Sch group, non-Sch group at Fz: (0.8 + or - 0.7) microV, (2.5 + or - 1.6) microV, (3.3 + or - 2.2) microV; latency: NC, Sch group, non-Sch group at Fz: (50 + or - 26) ms, (75 + or - 19) ms and (70 + or - 24) ms respectively] (P < 0.01), and no significant difference in amplitude and latency of S2-P50 between two Sch groups. (2) Compared with NC, two Sch groups showed a higher S2/S1 ratio [NC, Sch group, non-Sch group at Fz: 35 + or - 26, 153 + or - 137, 125 + or - 85, respectively], lower S2-S1 [NC, Sch group, non Sch group at Fz: 1.69 + or - 1.55, 0.08 + or - 2.41 and 0.17 + or - 2.30, respectively] and 100 (1-S2/S1) [NC, Sch group, non-Sch group at Fz: 65 + or - 26, -53 + or - 137 and -25 + or - 85 respectively] (P < 0.01). And there was no significant difference in S2/S1 ratio, S2-S1 and 100 (1-S2/S1) between two Sch groups. (3) Two Sch groups showed no significant difference in PANSS total, P scale, N scale, and G scale [Sch group: (110 + or - 27), (26 + or - 10), (29 + or - 7), (55 + or - 12); non Sch group: (105 + or - 27), (24 + or - 8), (28 + or - 10) and (53 + or - 12) respectively] (P > 0.05), and no significant correlation with S2/S1 ratio, S2-S1 and 100(1-S2/S1) (P > 0.05).

CONCLUSION

Sensory gating deficit exists in schizophrenic patients with and without homicide. And it can be quantified by measuring auditory evoked potential P50, but sensory gating P50 has no difference between schizophrenic patients with and without homicide.

目的

探讨有杀人行为和无杀人行为的精神分裂症患者感觉门控P50的变化。

方法

采用事件相关电位技术中的条件/测试范式，通过EGI 256密集阵列听觉双点击刺激，对26例有杀人行为的精神分裂症患者（精神分裂症组）、27例无杀人行为的精神分裂症患者（非精神分裂症组）和32名正常对照者（NC组）进行听觉诱发电位P50检测。同时，采用阳性与阴性症状量表（PANSS）对其临床症状进行评估。

结果

（1）与NC组相比，两个精神分裂症组的S1-P50波幅和潜伏期差异无统计学意义[波幅：NC组、精神分裂症组、非精神分裂症组在Fz点分别为（2.4±1.6）μV、（2.5±1.5）μV、（3.4±2.7）μV；潜伏期：NC组、精神分裂症组、非精神分裂症组在Fz点分别为（68±19）ms、（67±20）ms、（61±19）ms]，但S2-P50波幅升高、潜伏期延长[波幅：NC组、精神分裂症组、非精神分裂症组在Fz点分别为（0.8±0.7）μV、（2.5±1.6）μV、（3.3±2.2）μV；潜伏期：NC组、精神分裂症组、非精神分裂症组在Fz点分别为（50±26）ms、（75±19）ms、（70±24）ms]（P<0.01），两个精神分裂症组之间S2-P50波幅和潜伏期差异无统计学意义。（2）与NC组相比，两个精神分裂症组的S2/S1比值升高，S2-S1降低，100（1-S2/S1）降低[NC组、精神分裂症组、非精神分裂症组在Fz点分别为35±26、153±137、125±85；分别为1.69±1.55、0.08±2.41、0.17±2.30；分别为65±26、-53±137、-25±85]（P<0.01）。两个精神分裂症组之间S2/S1比值、S2-S1和100（1-S2/S1）差异无统计学意义。（3）两个精神分裂症组在PANSS总分、P因子、N因子和G因子方面差异无统计学意义[精神分裂症组：（110±27）、（26±10）、（29±7）、（55±12）；非精神分裂症组：（105±27）、（24±8）、（28±10）、（53±12）]（P>0.05），且与S2/S1比值、S2-S1和100（1-S2/S1）无显著相关性（P>0.05）。