Ghisolfi Eduardo S, Heldt Elizeth, Zanardo Ana Paula, Strimitzer Ivo M, Prokopiuk Alexandre S, Becker Jefferson, Cordioli Aristides V, Manfro Gisele G, Lara Diogo R
Departamento de Ciências Fisiológicas, Faculdade de Biociências da, Pontifícia Universidade Católica do Rio Grande do Sul, Av. Ipiranga, 6681 - Prédio 12 A, 90619-900 Porto Alegre, RS, Brazil.
J Psychiatr Res. 2006 Sep;40(6):535-40. doi: 10.1016/j.jpsychires.2006.02.006. Epub 2006 Apr 17.
Previous studies with prepulse inhibition in panic disorder (PD) have suggested that the early stages of sensory information processing are abnormal in patients with PD. To further investigate sensory gating function in panic disorder we performed a case-control study in a sample of 28 patients with PD, compared to 28 normal subjects and 28 schizophrenic subjects evaluating auditory mid-latency evoked potential P50 in a double-click paradigm as a measure of sensory gating. PD subjects showed weaker sensory gating as evidenced by higher P50 ratios as compared to normal subjects (62.5% vs. 45.4%, p=0.03) and higher S2 (test) amplitude (3.5 microV vs. 2.1 microV, p=0.01). Schizophrenic subjects when compared to healthy controls showed higher P50 ratios as compared to normal subjects (79.2% vs. 45.4%, p<0.01) and higher S2 amplitude (3.3 microV vs. 2.1 microV, p=0.01), but were not statistically different from PD subjects (p>0.1). The present study corroborates recent findings of sensory gating dysfunction in PD. Further studies are still necessary to better understand the pathophysiology of this neurophysiological dysfunction and its nature as a trait or a state marker.
先前关于惊恐障碍（PD）患者前脉冲抑制的研究表明，PD患者感觉信息处理的早期阶段存在异常。为了进一步研究惊恐障碍中的感觉门控功能，我们对28例PD患者、28例正常受试者和28例精神分裂症受试者进行了一项病例对照研究，在双击范式中评估听觉中潜伏期诱发电位P50，以此作为感觉门控的指标。与正常受试者相比，PD受试者的感觉门控较弱，表现为P50比率较高（62.5%对45.4%，p = 0.03）以及S2（测试）波幅较高（3.5微伏对2.1微伏，p = 0.01）。与健康对照相比，精神分裂症受试者的P50比率高于正常受试者（79.2%对45.4%，p<0.01），S2波幅也较高（3.3微伏对2.1微伏，p = 0.01），但与PD受试者无统计学差异（p>0.1）。本研究证实了近期关于PD患者感觉门控功能障碍的发现。仍需要进一步研究以更好地理解这种神经生理功能障碍的病理生理学及其作为特质或状态标志物的性质。
