正常衰老小鼠脑室扩大的寿命期 MRI 评估。

A lifespan MRI evaluation of ventricular enlargement in normal aging mice.

机构信息

Institute of Biomedical Sciences, Academic Sinica, Taipei, Taiwan, ROC.

出版信息

Neurobiol Aging. 2011 Dec;32(12):2299-307. doi: 10.1016/j.neurobiolaging.2010.01.013. Epub 2010 Feb 5.

DOI:10.1016/j.neurobiolaging.2010.01.013

PMID:20137831

Abstract

Ventricular enlargement has been proposed as a structural biomarker for the progression of Alzheimer's disease (AD). This biomarker, established in human patients, needs to be translated to animals to facilitate drug development for the disease. However, ventricular enlargement is not exclusive to AD, since the ventricle size increases during normal aging. A longitudinal characterization of ventricular enlargement in normal aging in mice is therefore crucial before further evaluations of mouse models or neurodegenerative diseases associated to brain atrophy. To this end, ventricular enlargement in normal aging mice was characterized over the lifespan (i.e., 2 years). The results showed that the overall ventricle size increased with age, with the expansion beginning during the early life stages and continuing to old age. The reported data represent a biomarker benchmark for normal aging mice under unmodified conditions. This provides a foundation for evaluating the validity of AD mouse models or the effects of potential drugs. The considerable physiological ventricular enlargement during normal aging must be considered in related experiments.

摘要

脑室扩大被认为是阿尔茨海默病（AD）进展的一种结构生物标志物。这个在人类患者中建立的生物标志物需要被转化为动物模型，以促进该疾病的药物研发。然而，脑室扩大并不仅限于 AD，因为心室大小会随着正常衰老而增加。因此，在进一步评估与脑萎缩相关的小鼠模型或神经退行性疾病之前，对正常衰老小鼠的脑室扩大进行纵向特征描述至关重要。为此，研究人员在整个生命周期（即 2 年）内对正常衰老小鼠的脑室扩大进行了特征描述。结果表明，整个心室大小随年龄增长而增加，扩张始于生命早期，并持续到老年。所报告的数据代表了未经修饰条件下正常衰老小鼠的生物标志物基准。这为评估 AD 小鼠模型或潜在药物的效果提供了基础。在相关实验中，必须考虑到正常衰老期间心室的显著生理性扩大。