Yamashita K, Tamaki N, Yonekura Y, Ohtani H, Magata Y, Nohara R, Kambara H, Kawai C, Ban T, Konishi J
Department of Radiology and Nuclear Medicine, Cardiovascular Surgery, Kyoto University, School of Medicine, Japan.
J Nucl Med. 1991 Apr;32(4):679-85.
Regional wall thickening was assessed by electrocardiographically gated positron emission tomography (ECG-gated PET) in 26 patients with coronary artery disease. The standardized percent count increase from end-diastole to end-systole (S-percent Cl) was calculated as an index of wall thickening. The S-percent Cl was 77.8% +/- 28.9% in the segments with normal perfusion at rest, 51.9% +/- 29.5% in those with mild hypoperfusion, and 32.8% +/- 30.9% in those with severe hypoperfusion (p less than 0.001, each). Among the segments with resting hypoperfusion, the S-percent Cl was 38.9% +/- 31.5% in those without stress-induced ischemia and 48.7% +/- 30.9% in those with ischemia (p less than 0.05). Furthermore, among resting severe hypoperfusion, the S-percent Cl was 23.0% +/- 23.9% in the segments without fluorine-18-fluorodeoxyglucose (FDG) uptake and 37.8 +/- 32.9% in those with FDG uptake (p less than 0.05). These results suggest that stress-induced ischemia and FDG accumulation correlated with wall thickening. Thus, quantitative analysis of regional wall thickening seems to be useful for combined analysis of regional function, perfusion and metabolism in coronary patients.
采用心电图门控正电子发射断层扫描（ECG门控PET）对26例冠心病患者的局部心肌壁增厚情况进行评估。计算舒张末期至收缩末期标准化计数增加百分比（S百分比Cl）作为心肌壁增厚指标。静息灌注正常节段的S百分比Cl为77.8%±28.9%，轻度灌注减低节段为51.9%±29.5%，重度灌注减低节段为32.8%±30.9%（均P<0.001）。在静息灌注减低节段中，无应激性心肌缺血节段的S百分比Cl为38.9%±31.5%，有心肌缺血节段为48.7%±30.9%（P<0.05）。此外，在静息重度灌注减低节段中，无氟-18-氟脱氧葡萄糖（FDG）摄取节段的S百分比Cl为23.0%±23.9%，有FDG摄取节段为37.8±32.9%（P<0.05）。这些结果提示，应激性心肌缺血和FDG积聚与心肌壁增厚相关。因此，局部心肌壁增厚的定量分析似乎有助于冠心病患者局部功能、灌注和代谢的综合分析。
