Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
FEBS Lett. 2010 Apr 2;584(7):1280-6. doi: 10.1016/j.febslet.2010.02.001. Epub 2010 Feb 5.
Autophagy is a system for degradation of bulk cellular components in lytic compartments, vacuoles, or lysosomes when eukaryotic cells face with nutrient starvation. In this review, we focus on the pre-autophagosomal structure (PAS), a functional entity responsible for autophagosome formation in Saccharomyces cerevisiae, and discuss its relevance to autophagy in mammalian cells.
自噬是一种在真核细胞面临营养饥饿时，通过溶酶体或液泡中的溶酶体降解大量细胞成分的系统。在这篇综述中，我们专注于前自噬体结构（PAS），这是一个在酿酒酵母中负责自噬体形成的功能实体，并讨论其与哺乳动物细胞自噬的相关性。
