Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Maheshnagar, Pimpri, Pune-18, Maharashtra, India.
Oral Oncol. 2010 Mar;46(3):146-53. doi: 10.1016/j.oraloncology.2009.12.009. Epub 2010 Feb 6.
Plasmablastic lymphoma (PBL) is a rare AIDS associated non-Hodgkin's lymphoma (NHL), with predilection for the mucosa of oral cavity. It usually has a plasmablastic morphology, expressing plasma cell-associated antigens with weak or no expression of B-cell associated markers. The tumor cells also show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of Ig light chain (IgL) gene expression in most of the cases. An etiological role for EBV seems likely but the association with HHV8 is questionable. The treatment guidelines for PBL are not well defined and patients have been treated heterogeneously with chemo and/or radiotherapy, although the prognosis is poor. The present article discusses the 68 cases reported in English medical literature with comprehensive review on PBL involving the oral cavity.
弥漫性大 B 细胞淋巴瘤（DLBCL）是一种常见的侵袭性非霍奇金淋巴瘤（NHL），在老年患者中发病率较高。尽管大多数 DLBCL 病例具有明确的临床病理特征和免疫表型，但仍有 10%～15%的病例无法明确诊断，这些病例被称为“DLBCL，NOS”或“DLBCL，不能分类”。这些病例的临床行为和预后与经典型 DLBCL 相似，但治疗策略和预后因素可能有所不同。本文将对这些病例的临床病理特征、治疗和预后进行综述，并探讨其在临床实践中的意义。
