School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Oral Oncol. 2010 Apr;46(4):226-31. doi: 10.1016/j.oraloncology.2010.01.007. Epub 2010 Feb 6.
Sensitive and reliable early diagnostic markers for oral squamous cell carcinoma (OSCC) remain unavailable. Early identification of recurrence for OSCC is also a challenge. Unlike the other deep cancers, OSCC is located in oral cavity. The DNA, RNA, and protein derived from the living cancer cells and inflammatory cells then can be conveniently obtained from saliva. High-throughput genomic and proteomic approaches have been carried out to identify the potential biomarkers in body fluids such as saliva and blood for diagnosis and prognosis of OSCC. This article reviewed the recently identified biomarkers from saliva for OSCC. In addition, the biomarkers which have been correlated with OSCC tumor malignancy by molecular pathology analysis are also described. Finally, the potential biomarkers that have been demonstrated to associate with the malignant OSCC may be used for salivary screening for high-risk patients are suggested. This article may help to identify the potential biomarkers for screening and the molecular pathology analysis for high-risk patients of OSCC. Effective screening to identify high-risk patients can allow the clinician to provide the appropriate treatment without delay and to reduce the recurrence of OSCC.
用于口腔鳞状细胞癌 (OSCC) 的敏感且可靠的早期诊断标志物仍然缺乏。OSCC 的早期复发识别也是一个挑战。与其他深部癌症不同，OSCC 位于口腔内。来自活癌细胞和炎症细胞的 DNA、RNA 和蛋白质可以方便地从唾液中获得。已经进行了高通量基因组和蛋白质组学方法来鉴定来自唾液和血液等体液中的潜在生物标志物，用于诊断和预测 OSCC。本文综述了最近从唾液中鉴定出的用于 OSCC 的生物标志物。此外，还描述了通过分子病理学分析与 OSCC 肿瘤恶性程度相关的生物标志物。最后，建议使用与恶性 OSCC 相关的潜在生物标志物进行高危患者的唾液筛查。本文可能有助于识别用于 OSCC 高危患者筛查和分子病理学分析的潜在生物标志物。有效的筛查可以识别高危患者，使临床医生能够及时提供适当的治疗，并降低 OSCC 的复发率。
