Salemark L, Wieslander J B, Dougan P, Arnljots B
Department of Experimental Research, Malmö General Hospital, Sweden.
J Reconstr Microsurg. 1991 Jan;7(1):27-30. doi: 10.1055/s-2007-1006761.
The efficacy of topical prostacyclin as an antithrombotic agent was tested in a model of microvascular trauma. Preliminary measurements were made to determine a suitable dosage. Twenty-seven central arteries of rabbit ears were then prepared and 32P-labelled platelets infused intraaortically. Arteriotomy (7 mm) was followed by intimectomy (5 mm). Fifteen vessels in a control group were irrigated with Ringer's lactate and 12 vessels in an experimental group were treated with prostacyclin (10 ng/ml) in normal saline. Bleeding times at the sites of arteriotomy intimectomy, in vivo accumulations of isotope-labelled platelets, amounts of red thrombotic material, and patency were recorded. Patency was lower following prostacyclin treatment (1/12 as against 5/15) but not significantly so, and there were no statistically significant differences in other parameters. Prostacyclin treatment decreased vessel wall tone, interfering with blood-flow and promoting thrombus formation.
在微血管创伤模型中测试了局部用前列环素作为抗血栓形成剂的功效。进行了初步测量以确定合适的剂量。然后制备了27只兔耳的中央动脉，并经主动脉内注入32P标记的血小板。动脉切开术（7毫米）后进行内膜切除术（5毫米）。对照组的15条血管用乳酸林格液冲洗，实验组的12条血管用生理盐水中的前列环素（10纳克/毫升）处理。记录动脉切开术内膜切除部位的出血时间、同位素标记血小板的体内积聚量、红色血栓物质的量和通畅情况。前列环素治疗后的通畅率较低（1/12对5/15），但差异不显著，其他参数也无统计学显著差异。前列环素治疗降低了血管壁张力，干扰了血流并促进了血栓形成。
