Wieslander J B, Dougan P, Stjernquist U, Mecklenburg C V
Microsurgery. 1986;7(4):168-77. doi: 10.1002/micr.1920070409.
Twenty-four arteries of rabbit ears, divided into three groups of eight, were prepared and 32P-platelets injected. Arteriotomy (7 mm) and intimectomy (5 mm) were performed and in vivo platelet accumulation followed for 2 hours. Group A comprised untreated control animals, group B was treated with 17 ml saline/kg bw, and group C with 1 g dextran and 17 ml saline/kg bw (Macrodex). Significant differences in platelet accumulation were observed only between the control and Macrodex groups at 105 and 120 minutes. In the control and saline groups four of eight vessels showed poor or no patency. All Macrodex vessels showed good patency. Control and saline vessels had large amounts of red thrombotic material, except for three saline cases with small amounts. After Macrodex treatment five of eight vessels were apparently clean, while the other three showed only small amounts of red thrombotic material. Dextran seems not to influence platelet function but rather to inhibit fibrin stabilization and probably increases fibrinolysis. Vascular patency was only endangered by the formation of solid fibrin-containing red thrombi.
将兔耳的24条动脉分为三组，每组8条，制备后注射32P标记的血小板。进行动脉切开术（7毫米）和内膜切除术（5毫米），并在体内追踪血小板聚集2小时。A组为未处理的对照动物，B组用17毫升生理盐水/千克体重处理，C组用1克右旋糖酐和17毫升生理盐水/千克体重（Macrodex）处理。仅在105和120分钟时，对照和Macrodex组之间观察到血小板聚集有显著差异。在对照和生理盐水组中，八条血管中有四条显示通畅性差或无通畅。所有Macrodex处理的血管均显示良好的通畅性。对照和生理盐水处理的血管有大量红色血栓物质，除了三例生理盐水处理的病例有少量。Macrodex处理后，八条血管中有五条明显干净，而另外三条仅显示少量红色血栓物质。右旋糖酐似乎不影响血小板功能，而是抑制纤维蛋白稳定，可能增加纤维蛋白溶解。血管通畅仅因含纤维蛋白的红色血栓形成而受到威胁。
