左卡巴斯汀鼻喷雾剂显著改善常年性变应性鼻炎：一项单盲安慰剂对照研究。
Levocabastine nasal spray significantly improves perennial allergic rhinitis: a single-blind placebo-controlled study.
作者信息
Okubo Kimihiro, Uchida Eiji, Nogami Shoji
机构信息
Department of Otolaryngology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
出版信息
Auris Nasus Larynx. 2010 Aug;37(4):436-42. doi: 10.1016/j.anl.2009.11.014. Epub 2010 Feb 6.
OBJECTIVE
The efficacy of levocabastine nasal spray for relieving the symptoms of perennial allergic rhinitis was compared with placebo in a single-blind study.
METHODS
Three hundred and thirty-five patients with moderate to severe perennial allergic rhinitis were randomized to three groups that were administered a high or low dose of levocabastine nasal spray or a placebo. Patients were not informed of their treatment. Efficacy was evaluated based on the changes of symptoms and rhinoscopy findings.
RESULTS
Significant improvement of symptoms was observed in both the high-dose and low-dose levocabastine groups compared with the placebo group. There were no significant differences of efficacy between the high-dose and low-dose levocabastine groups. There was also no significant difference in the occurrence of adverse effects among the three groups.
CONCLUSION
Levocabastine nasal spray is a safe and effective treatment for perennial allergic rhinitis.
目的
在一项单盲研究中，将左卡巴斯汀鼻喷雾剂缓解常年性变应性鼻炎症状的疗效与安慰剂进行比较。
方法
335例中重度常年性变应性鼻炎患者被随机分为三组，分别给予高剂量或低剂量左卡巴斯汀鼻喷雾剂或安慰剂。患者未被告知其接受的治疗。根据症状变化和鼻镜检查结果评估疗效。
结果
与安慰剂组相比，高剂量和低剂量左卡巴斯汀组的症状均有显著改善。高剂量和低剂量左卡巴斯汀组之间的疗效无显著差异。三组之间不良反应的发生率也无显著差异。
结论
左卡巴斯汀鼻喷雾剂是治疗常年性变应性鼻炎的一种安全有效的药物。
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