INSERM U848, 94805 Villejuif Cedex, France.
Trends Biochem Sci. 2010 May;35(5):278-87. doi: 10.1016/j.tibs.2009.12.008. Epub 2010 Feb 6.
Apoptosis-inducing factor (AIF) was initially discovered as a caspase-independent death effector. AIF fulfills its lethal function after its release from mitochondria and its translocation to the nucleus of the dying cell. The contribution of AIF to programmed cell death is dependent upon the cell type and apoptotic insult. Recent in vivo data indicate that, in addition to its lethal activity, AIF plays a vital mitochondrial role in healthy cells. A segment of AIF which is dispensable for its apoptotic function carries an NADH-oxidase domain that regulates the respiratory chain complex I and is required for cell survival, proliferation and mitochondrial integrity. Mice that express reduced levels of AIF constitute a reliable model of complex I deficiency. Here we discuss recent reports on the survival-related function(s) of AIF.
凋亡诱导因子 (AIF) 最初被发现是一种 caspase 非依赖性的死亡效应因子。AIF 在从线粒体释放并转移到垂死细胞的核后，发挥其致死功能。AIF 对细胞程序性死亡的贡献取决于细胞类型和凋亡刺激。最近的体内数据表明，除了其致死活性外，AIF 在健康细胞中还具有重要的线粒体作用。AIF 的一段对于其凋亡功能来说是可有可无的，带有 NADH 氧化酶结构域，该结构域调节呼吸链复合物 I，是细胞存活、增殖和线粒体完整性所必需的。表达低水平 AIF 的小鼠构成了复合物 I 缺乏的可靠模型。在这里，我们讨论了关于 AIF 的生存相关功能的最新报告。
