Institute of Molecular and Cellular Biology, University of Leeds, Clarendon Way, Leeds LS2 9JT, United Kingdom.
Exp Parasitol. 2010 Nov;126(3):406-14. doi: 10.1016/j.exppara.2010.01.028. Epub 2010 Feb 6.
Malaria, a disease caused by the protozoan parasite Plasmodium, remains a serious healthcare problem in developing countries worldwide. While the host-parasite relationship in humans has been difficult to determine, the pliability of murine malaria models has enabled valuable contributions to the understanding of the pathogenesis of disease. Although no single model reflects precisely malaria infection of the human, different models collectively provide important information on the mechanisms of protective immunity and immunopathogenesis. This review summarizes progress towards understanding the broad spectrum of immune responsiveness to the blood stages of the malaria parasite during experimental infections in mice and highlights how examination of murine malarias sheds light on the factors involved in the modulation of vaccine-potentiated immunity.
疟疾是一种由原生动物寄生虫疟原虫引起的疾病，在世界范围内的发展中国家仍然是一个严重的医疗保健问题。虽然人类的宿主-寄生虫关系很难确定，但鼠疟模型的可变性使得对疾病发病机制的理解做出了有价值的贡献。虽然没有单一的模型能准确反映人类疟疾感染，但不同的模型共同提供了关于保护性免疫和免疫发病机制的重要信息。这篇综述总结了在实验性感染小鼠的血液阶段疟原虫过程中，对广泛的免疫反应的理解所取得的进展，并强调了检查鼠疟如何揭示了调节疫苗增强免疫的因素。
