接触生物质烟雾导致 COPD 的风险：荟萃分析。

Risk of COPD from exposure to biomass smoke: a metaanalysis.

机构信息

Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, Guangdong, 510120, China.

出版信息

Chest. 2010 Jul;138(1):20-31. doi: 10.1378/chest.08-2114. Epub 2010 Feb 5.

DOI:10.1378/chest.08-2114

PMID:20139228

Abstract

BACKGROUND

Although many studies have suggested that biomass smoke is a risk factor for COPD, the relationship between the two has not been firmly established. In particular, the extent of the association between exposure of biomass smoke and COPD in different populations, as well as the relationship between biomass smoke and cigarette smoke, is not clear. To ascertain the relationship between biomass smoke and COPD, we performed a metaanalysis.

METHODS

We searched MEDLINE, EMBASE, and the Latin American and Caribbean Literature in Health Sciences Database and analyzed 15 epidemiologic (11 cross-sectional and four case-control) studies that met our criteria. Data were extracted and analyzed independently by two investigators using a standardized protocol.

RESULTS

Overall, people exposed to biomass smoke have an odds ratio (OR) of 2.44 (95% CI, 1.9-3.33) for developing COPD, relative to those not exposed to biomass smoke. Biomass smoke exposure was clearly identified as a risk factor for developing COPD in both women (OR, 2.73; 95% CI, 2.28-3.28) and men (OR, 4.30; 95% CI, 1.85-10.01), and in both the Asian population (OR, 2.31; 95% CI, 1.41-3.78) and the non-Asian population (OR, 2.56; 95% CI, 1.71-3.83). This risk factor has also been revealed in patients with chronic bronchitis (OR, 2.56; 95% CI, 1.77-3.70) and COPD (OR, 2.65; 95% CI, 1.75-4.03), and in cigarette smokers (OR, 4.39; 95% CI, 1.40-4.66) and non-cigarette smokers (OR, 2.55; 95% CI, 2.06-3.15).

CONCLUSIONS

Exposure to biomass smoke is a risk factor for COPD.

摘要

背景

尽管许多研究表明生物质烟雾是 COPD 的一个危险因素，但两者之间的关系尚未得到确定。特别是，在不同人群中，生物质烟雾暴露与 COPD 之间的关联程度，以及生物质烟雾与香烟烟雾之间的关系尚不清楚。为了确定生物质烟雾与 COPD 之间的关系，我们进行了荟萃分析。

方法

我们检索了 MEDLINE、EMBASE 和拉丁美洲和加勒比地区健康科学文献数据库，并分析了符合我们标准的 15 项流行病学（11 项横断面研究和 4 项病例对照研究）研究。数据由两名研究人员使用标准化方案独立提取和分析。

结果

总体而言，与未暴露于生物质烟雾的人相比，暴露于生物质烟雾的人患 COPD 的比值比（OR）为 2.44（95%CI，1.9-3.33）。在女性（OR，2.73；95%CI，2.28-3.28）和男性（OR，4.30；95%CI，1.85-10.01）、亚洲人群（OR，2.31；95%CI，1.41-3.78）和非亚洲人群（OR，2.56；95%CI，1.71-3.83）中，生物质烟雾暴露均被明确认定为患 COPD 的危险因素。在慢性支气管炎患者（OR，2.56；95%CI，1.77-3.70）和 COPD 患者（OR，2.65；95%CI，1.75-4.03）中，以及在香烟吸烟者（OR，4.39；95%CI，1.40-4.66）和非香烟吸烟者（OR，2.55；95%CI，2.06-3.15）中，也发现了这一危险因素。