Robles-Hernández Robinson, Rivera Rosa María, Páramo-Pérez Marcos, Quiroz-Camacho Dulce Mariana, Centeno-Saenz Gustavo I, Bedolla-Tinoco Alan, Maya-García María C, Pérez-Padilla Rogelio
Departamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias, Mexico City 14080, Mexico.
Departamento de Patología, Instituto Nacional de Enfermedades Respiratorias, Mexico City 14080, Mexico.
Biomedicines. 2025 Jun 30;13(7):1593. doi: 10.3390/biomedicines13071593.
Chronic Obstructive Pulmonary Disease (COPD) exhibits some phenotypic differences between patients with biomass smoke inhalation (COPD-B) and tobacco smoking (COPD-T). COPD-B is characterized by less emphysema but more airway disease and vascular pulmonary remodeling, which are related to mast cells in lung tissues in COPD-T. Our objective was to describe the differences between the number of mast cells in COPD-B and COPD-T patients. : A cross-sectional study was conducted on lung tissue resections for suspected cancer obtained between 2014 and 2021 from patients with documented COPD due to wood smoke or tobacco exposure. Histological samples were analyzed for mast cell count, CD34+ expression, and structural changes in lung tissue and pulmonary circulation. : A total of 20 histological samples were analyzed, with significant differences found in mast cell count [median 8 (p25-75, 5-11) vs. 2 (p75-25, 0-6), = 0.016] and severe peribronchiolar fibrosis (60% vs. 10%, = 0.04) between COPD-B and COPD-T patients. A positive correlation [Spearman rho = 0.879 (95% CI 0.71-0.96), < 0.001] was observed between mast cell count and a gradual increase in pulmonary artery diameter. : These preliminary findings suggest histological differences and the presence of mast cells between COPD-B and COPD-T, which should be confirmed in a larger number of samples and patients.
慢性阻塞性肺疾病（COPD）在生物质烟雾吸入患者（COPD-B）和吸烟患者（COPD-T）之间表现出一些表型差异。COPD-B的特征是肺气肿较轻，但气道疾病和肺血管重塑较多，这与COPD-T肺组织中的肥大细胞有关。我们的目的是描述COPD-B和COPD-T患者肥大细胞数量的差异。：对2014年至2021年间因木材烟雾或烟草暴露而患有COPD的患者进行了疑似癌症的肺组织切除术的横断面研究。对组织学样本进行了肥大细胞计数、CD34+表达以及肺组织和肺循环结构变化的分析。：共分析了20个组织学样本，发现COPD-B和COPD-T患者在肥大细胞计数[中位数8（第25-75百分位数，5-11）对2（第75-25百分位数，0-6），P=0.016]和严重的细支气管周围纤维化（60%对10%，P=0.04）方面存在显著差异。在肥大细胞计数与肺动脉直径逐渐增加之间观察到正相关[Spearman相关系数=0.879（95%CI 0.71-0.96），P<0.001]。：这些初步发现表明COPD-B和COPD-T之间存在组织学差异和肥大细胞的存在，这应在更多样本和患者中得到证实。
