Ste12及类Ste12蛋白，即调节发育和致病性的真菌转录因子。
Ste12 and Ste12-like proteins, fungal transcription factors regulating development and pathogenicity.
作者信息
Wong Sak Hoi Joanne, Dumas Bernard
机构信息
Université de Toulouse, UPS, Surfaces Cellulaires et Signalisation chez les Végétaux, Castanet-Tolosan, France.
出版信息
Eukaryot Cell. 2010 Apr;9(4):480-5. doi: 10.1128/EC.00333-09. Epub 2010 Feb 5.
Abstract
Ste12 and Ste12-like proteins are transcription factors found exclusively in the fungal kingdom. In the yeast model Saccharomyces cerevisiae, where the first member was identified, Ste12p was shown to regulate mating and invasive/pseudohyphal growth. In recent literature, there have been several reports of Ste12-like factors in multiple fungal systems, yeasts or filamentous fungi, with saprophytic or parasitic life-styles. In all these models, Ste12 and Ste12-like factors are involved in the regulation of fungal development and pathogenicity. In this review, we discuss the features, the regulation, and the role of Ste12 and Ste12-like factors by highlighting the similarities and dissimilarities that occur within this group.
摘要
Ste12及类Ste12蛋白是仅在真菌界发现的转录因子。在首个成员被鉴定出的酵母模型酿酒酵母中，Ste12p被证明可调控交配及侵袭性/假菌丝生长。在最近的文献中，有几篇关于多种真菌系统（酵母或丝状真菌，具有腐生或寄生生活方式）中类Ste12因子的报道。在所有这些模型中，Ste12及类Ste12因子都参与真菌发育和致病性的调控。在本综述中，我们通过强调该组内出现的异同来讨论Ste12及类Ste12因子的特征、调控及作用。
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