The Danish Epidemiology Science Centre, Department of Epidemiology, School of Public Health, University of Aarhus, Bartholins Allé 2, 8000 Aarhus C, Denmark.
Hum Reprod. 2010 Apr;25(4):908-13. doi: 10.1093/humrep/deq010. Epub 2010 Feb 6.
It has previously been reported that children born after infertility treatment had a slight delay in early motor milestones. In this study, we examined whether children of infertile couples with or without infertility treatment had a higher risk of developmental coordination disorder (DCD).
We used data on parental infertility and DCD among 23 167 singletons from the Danish National Birth Cohort (1996-2002). Data on time to pregnancy (TTP) and infertility treatment were collected early in pregnancy. Data on DCD in children were collected using the Developmental Coordination Disorder Questionnaire, filled in by the mothers during follow-up when the children were 7 years old. We used the recommended cut-off for the age group to classify children.
Compared with children born of fertile couples, children conceived after a waiting TTP of longer than 12 months had a slightly higher risk of DCD [odds ratio (OR) 1.35, 95% confidence interval (CI) 1.03-1.77], but the estimated OR was not significant in children born after infertility treatment (OR 1.19, 95% CI 0.86-1.66). None of the individual treatment procedures was significantly associated with a higher risk of DCD. Children of parents who had not planned their pregnancy showed no elevated risk.
Our findings are overall reassuring, although it is possible that low fecundity may be associated with a modestly increased risk of DCD.
此前有报道称，经过不孕治疗出生的儿童在早期运动里程碑方面稍有延迟。在这项研究中，我们研究了有无不孕治疗的不孕夫妇所生的儿童是否更易患发育协调障碍（DCD）。
我们使用了来自丹麦全国出生队列（1996-2002 年）的 23167 名单胎儿童的父母不孕和 DCD 数据。妊娠早期收集了关于受孕时间（TTP）和不孕治疗的数据。通过使用发展协调障碍问卷收集了儿童的 DCD 数据，在随访期间，由母亲在孩子 7 岁时填写问卷。我们使用了适合该年龄组的推荐截止值来对儿童进行分类。
与生育能力正常的夫妇所生的儿童相比，等待 TTP 超过 12 个月后受孕的儿童 DCD 的风险略高（比值比 [OR] 1.35，95%置信区间 [CI] 1.03-1.77），但不孕治疗后出生的儿童的估计 OR 并不显著（OR 1.19，95% CI 0.86-1.66）。没有任何单一的治疗程序与 DCD 风险增加显著相关。未计划怀孕的父母所生的儿童没有显示出更高的风险。
我们的研究结果总体上令人安心，尽管低生育能力可能与 DCD 风险略有增加有关。
