Nag Shweta, Saraswathi T R, Sekhar Ganthimathy, Einstein A, Sivapathasundharam B
Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College and Hospital, Alapakkam Main Road, Maduravoyal, Chennai-600 095, Tamil Nadu, India.
Indian J Dent Res. 2009 Oct-Dec;20(4):503-5. doi: 10.4103/0970-9290.59446.
Non-necrotizing granulomas are occasionally seen in patients with certain malignant disorders and are termed as "sarcoid-like reaction," which have many similarities with sarcoidosis. Sarcoidosis is a multisystem granulomatous disease of unknown etiology characterized by organ involvement and interference of organ function by granuloma or fibrosis. Sarcoidosis is occasionally found in a variety of malignant diseases with an overall incidence of 4.4% in carcinoma patients. We present here a rare case of moderately differentiated squamous cell carcinoma of alveolar mucosa with regard to mandible associated with sarcoid-like reaction of cervical lymph nodes in a female patient in the absence of clinical evidence of systemic sarcoidosis. The relevant literature including pathogenesis is also discussed.
非坏死性肉芽肿偶尔可见于某些恶性疾病患者，被称为“结节病样反应”，与结节病有许多相似之处。结节病是一种病因不明的多系统肉芽肿性疾病，其特征是器官受累以及肉芽肿或纤维化对器官功能的干扰。结节病偶尔在各种恶性疾病中发现，在癌症患者中的总体发生率为4.4%。本文报告一例罕见的女性患者，下颌骨牙槽黏膜中度分化鳞状细胞癌伴颈部淋巴结结节病样反应，且无系统性结节病的临床证据。还讨论了包括发病机制在内的相关文献。
