Kim Jong Hoon, Kim Yong Ook, Jeun Jungae, Choi Duck-Young, Shin Chul Soo
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seodaemun-gu, Seoul, South Korea.
Biosci Biotechnol Biochem. 2010;74(2):304-8. doi: 10.1271/bbb.90620. Epub 2010 Feb 7.
High-fat diets (HFDs) supplemented with the L-Trp and L-Leu-OEt derivatives of the monascus pigment were fed to mice. Compared to the HFD group, the average body weight gain of the four HFD-pigment groups was decreased by 13.6-50.9%, and the intra-peritoneal adipose tissues weight was reduced by 16.7-30.5%. The derivatives also reduced the respective serum total cholesterol and triglyceride levels of the mice by 9.7-14.4% and 12.5-17.2%. The L-Trp derivative greatly increased the HDL-cholesterol level by 64.8-66.4% and the HTR value by 73.8-81.7%. The L-Leu-OEt and L-Trp derivatives decreased the total cholesterol level in the mice liver by 9.7-24.2% and 36.2-39.9%, respectively. Reductions in the triglyceride level were 21.5-22.4% for the L-Leu-OEt derivative and 17.9-18.8% for the L-Trp derivative. The L-Leu-OEt derivative exhibited higher in vitro inhibitory activities against HMG-CoA reductase and lipoprotein lipase than the L-Trp derivative. An in vivo test with mice showed the L-Trp derivative to have higher anti-obesity effects than the L-Leu-OEt derivative.
将补充了红曲色素的L-色氨酸和L-亮氨酸乙酯衍生物的高脂饮食（HFD）喂给小鼠。与HFD组相比，四个HFD-色素组的平均体重增加降低了13.6 - 50.9%，腹膜内脂肪组织重量减少了16.7 - 30.5%。这些衍生物还使小鼠的血清总胆固醇和甘油三酯水平分别降低了9.7 - 14.4%和12.5 - 17.2%。L-色氨酸衍生物使高密度脂蛋白胆固醇水平大幅提高了64.8 - 66.4%，HTR值提高了73.8 - 81.7%。L-亮氨酸乙酯和L-色氨酸衍生物分别使小鼠肝脏中的总胆固醇水平降低了9.7 - 24.2%和36.2 - 39.9%。L-亮氨酸乙酯衍生物使甘油三酯水平降低了21.5 - 22.4%，L-色氨酸衍生物使甘油三酯水平降低了17.9 - 18.8%。L-亮氨酸乙酯衍生物在体外对HMG-CoA还原酶和脂蛋白脂肪酶的抑制活性高于L-色氨酸衍生物。对小鼠的体内试验表明，L-色氨酸衍生物的抗肥胖作用比L-亮氨酸乙酯衍生物更强。
