van Buuren Stef
Department of Statistics, TNO Quality of Life, Leiden, The Netherlands.
Nestle Nutr Workshop Ser Pediatr Program. 2010;65:167-75; discussion 175-9. doi: 10.1159/000281161. Epub 2010 Feb 1.
Exclusively breastfed (EBF) infants have higher weight gain during the first 2 months, and lower thereafter. The explanation for this phenomenon is not clear. Longitudinal data from the Social Medical Survey of Children Attending Child Health Clinics study with a cohort of 2,151 Dutch children were analyzed according to a pattern mixture model. It appears that higher than average growth of EBF infants during the first 2 months is primarily attributable to selective dropout. Furthermore, between months 2 and 6, light nonEBF infants gain more weight than light EBF infants. Both factors aid in explaining differences in growth between EBF and nonEBF infants. The WHO Child Growth Standards for weight-for-age have been calculated from a subgroup of 903 infants (out of 1,743) that complied with strict feeding criteria. If similar dropout mechanisms operate in the Multicentre Growth Reference Study, then the WHO weight-for-age standards are expected to be systematically different from those for the entire group of 1,743 infants.
纯母乳喂养（EBF）的婴儿在出生后的前两个月体重增加较快，之后则较慢。这种现象的原因尚不清楚。我们根据模式混合模型分析了来自儿童健康诊所儿童社会医学调查研究的纵向数据，该研究队列包括2151名荷兰儿童。结果显示，纯母乳喂养婴儿在头两个月高于平均水平的生长主要归因于选择性失访。此外，在2至6个月期间，轻度非纯母乳喂养婴儿比轻度纯母乳喂养婴儿体重增加更多。这两个因素有助于解释纯母乳喂养和非纯母乳喂养婴儿之间的生长差异。世界卫生组织（WHO）年龄别体重生长标准是根据1743名婴儿中的903名符合严格喂养标准的婴儿亚组计算得出的。如果多中心生长参考研究中存在类似的失访机制，那么预计WHO年龄别体重标准将与1743名婴儿的整个群体的标准存在系统性差异。
