有丝分裂原激活的蛋白激酶磷酸酶与癌症。
Mitogen activated protein kinase phosphatases and cancer.
机构信息
Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI, USA.
出版信息
Cancer Biol Ther. 2010 Mar 1;9(5):337-40. doi: 10.4161/cbt.9.5.11217. Epub 2010 Mar 17.
Abstract
Deregulation of cell signaling is a vital part of cancer development. The mitogen activated protein kinase (MAPK) family is involved in regulating both cell growth and cell death. This family of kinases is negatively regulated by mitogen activated protein kinase phosphatases (MKPs). MKPs are dual specificity phosphatases that target threonine and tyrosine residues that appear in a TXY motif. There are eleven members of the MKP family. Expression of MKPs has been shown to be altered in many different types of cancer. Most of what is known centers on MKP-1, MKP-2 and MKP-3. This review will focus on their role in cancer development and progression.
摘要
细胞信号转导的失调是癌症发展的重要组成部分。丝裂原激活的蛋白激酶（MAPK）家族参与调节细胞生长和细胞死亡。该激酶家族受丝裂原激活的蛋白激酶磷酸酶（MKP）的负调控。MKP 是双重特异性磷酸酶，可靶向 TXY 基序中的苏氨酸和酪氨酸残基。MKP 家族有十一个成员。MKP 的表达已在许多不同类型的癌症中发生改变。目前已知的大部分内容都集中在 MKP-1、MKP-2 和 MKP-3 上。本综述将重点介绍它们在癌症发展和进展中的作用。
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