Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Clin Nucl Med. 2009 Dec;34(12):848-53. doi: 10.1097/RLU.0b013e3181becdfc.
Primary breast lymphoma (PBL) is a rare disease and its management differs from other breast cancers. The purpose of this study is to evaluate the role of FDG PET-CT in the management of PBL. We carried out 16 PET-CT scans and reviewed the literature.
A total of 16 FDG PET-CT scans were done in 8 female patients with PBL with a median age of 49 years (range: 27-68). Of the 16 PET-CT scans, 1 scan was done for primary diagnosis and staging (1 patient), 2 for staging (2 patients), 7 for evaluation of treatment response (6 patients), and 6 for detecting recurrence (4 patients). PET-CT image interpretation and analysis were performed qualitatively (visually) and semiquantitatively using standardized uptake value (SUV). Absence of uptake in the postchemotherapy follow-up PET-CT scan was considered as a complete response, and a fall of more than 50% of baseline SUV was considered as a significant response.
One patient was successfully diagnosed to have PBL and staged using PET-CT. Two patients were correctly staged with the help of FDG PET-CT. Complete response was noted in all 6 patients (3 had a positive baseline scan and showed complete resolution of FDG uptake, the other 3 who did not have baseline PET-CT and lesions were detected on CT, and also showed complete resolution). Of the 4 patients evaluated for recurrence, 1 patient was positive and 3 patients were negative for recurrence in follow-up PET-CT scans done after 18, 22, and 24 months, respectively.
FDG PET-CT has a definitive role in every step of management (diagnosis, staging, treatment response evaluation, and detection of recurrence) in patients with primary breast lymphoma.
原发性乳腺淋巴瘤（PBL）是一种罕见疾病，其治疗方法与其他乳腺癌不同。本研究旨在评估 FDG PET-CT 在 PBL 管理中的作用。我们进行了 16 次 PET-CT 扫描，并复习了文献。
共对 8 例 PBL 女性患者进行了 16 次 FDG PET-CT 检查，中位年龄为 49 岁（范围：27-68 岁）。16 次 PET-CT 扫描中，1 次用于原发性诊断和分期（1 例患者），2 次用于分期（2 例患者），7 次用于评估治疗反应（6 例患者），6 次用于检测复发（4 例患者）。PET-CT 图像的解释和分析是定性（视觉）和半定量进行的，使用标准化摄取值（SUV）。在化疗后随访 PET-CT 扫描中无摄取被认为是完全缓解，SUV 基线下降超过 50%被认为是显著缓解。
1 例患者成功通过 PET-CT 诊断为 PBL 并进行分期。2 例患者借助 FDG PET-CT 正确分期。6 例患者均出现完全缓解（3 例基线扫描阳性，显示 FDG 摄取完全消退；另外 3 例无基线 PET-CT，CT 发现病变，也显示完全消退）。4 例评估复发的患者中，1 例在随访 PET-CT 扫描中阳性，另外 3 例在 18、22 和 24 个月后分别阴性。
FDG PET-CT 在原发性乳腺淋巴瘤患者的管理的每个步骤（诊断、分期、治疗反应评估和复发检测）中都具有明确的作用。
