Covington Matthew F, Koppula Bhasker R, Fine Gabriel C, Salem Ahmed Ebada, Wiggins Richard H, Hoffman John M, Morton Kathryn A
Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84132, USA.
Department of Radiodiagnosis and Intervention, Faculty of Medicine, Alexandria University, Alexandria 21526, Egypt.
Cancers (Basel). 2022 May 29;14(11):2689. doi: 10.3390/cancers14112689.
Positron emission tomography combined with x-ray computed tomography (PET-CT) is an advanced imaging modality with oncologic applications that include staging, therapy assessment, restaging, and surveillance. This six-part series of review articles provides practical information to providers and imaging professionals regarding the best use of PET-CT for the more common adult malignancies. The second article of this series addresses primary thoracic malignancy and breast cancer. For primary thoracic malignancy, the focus will be on lung cancer, malignant pleural mesothelioma, thymoma, and thymic carcinoma, with an emphasis on the use of FDG PET-CT. For breast cancer, the various histologic subtypes will be addressed, and will include F fluorodeoxyglucose (FDG), recently Food and Drug Administration (FDA)-approved F-fluoroestradiol (FES), and F sodium fluoride (NaF). The pitfalls and nuances of PET-CT in breast and primary thoracic malignancies and the imaging features that distinguish between subcategories of these tumors are addressed. This review will serve as a resource for the appropriate roles and limitations of PET-CT in the clinical management of patients with breast and primary thoracic malignancies for healthcare professionals caring for adult patients with these cancers. It also serves as a practical guide for imaging providers, including radiologists, nuclear medicine physicians, and their trainees.
正电子发射断层扫描与X射线计算机断层扫描相结合（PET-CT）是一种先进的成像方式，在肿瘤学领域有多种应用，包括分期、治疗评估、再分期和监测。这六部分的系列综述文章为医疗服务提供者和影像专业人员提供了关于PET-CT在更常见成人恶性肿瘤中最佳应用的实用信息。本系列的第二篇文章涉及原发性胸部恶性肿瘤和乳腺癌。对于原发性胸部恶性肿瘤，重点将放在肺癌、恶性胸膜间皮瘤、胸腺瘤和胸腺癌上，重点是FDG PET-CT的应用。对于乳腺癌，将讨论各种组织学亚型，包括氟脱氧葡萄糖（FDG）、最近获得美国食品药品监督管理局（FDA）批准的氟雌二醇（FES）和氟化钠（NaF）。文中还讨论了PET-CT在乳腺癌和原发性胸部恶性肿瘤中的陷阱和细微差别，以及区分这些肿瘤亚类的影像学特征。本综述将为医疗保健专业人员在乳腺癌和原发性胸部恶性肿瘤患者临床管理中PET-CT的适当作用和局限性提供参考，这些专业人员负责照顾患有这些癌症的成年患者。它还为影像提供者，包括放射科医生、核医学医生及其学员提供了实用指南。
