Department of Psychiatry, Dong Suh Mental Hospital and Paik Institute for Clinical Research, Inje University, Busan, Korea.
Psychiatry Investig. 2009 Dec;6(4):299-305. doi: 10.4306/pi.2009.6.4.299. Epub 2009 Nov 11.
The primary purpose of this study was to investigate the differences in the serum brain-derived neurotrophic factor (BDNF) level between elderly Korean people over 65 years with and without dementia.
171 individuals over 65 years were enrolled in this study. Screening for cognitive impairments was carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). One hundred thirty-two subjects scored below 1.5 standard deviations (SD) of the mean MMSE-KC score, and these were evaluated using the Consortium to Establish a Registry for Alzheimer's Disease, Korean version (CERAD-K) and the Geriatric Depression Scale (GDS). The Clinical Dementia Rating Scale (CDRS) and the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) diagnostic criteria were used for further evaluation. Subjects with a CDRS score of 1 or higher were classified as having Alzheimer's disease (AD), and subjects with a CDRS score of 0.5 were classified as having a mild cognitive impairment (MCI). Subjects with a CDRS score of 0 were classified as having aging-associated cognitive decline (AACD). Serum BDNF levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) method.
The serum BDNF levels were significantly lower in the subjects with MCI and AD compared with the healthy controls (p<0.01). A significant correlation was found between the total MMSE-KC score and serum BDNF level (r=0.295; p<0.01). However, no significant correlation was observed between the severity of MMSE-KC and the total GDS score. A significant difference was found in the total score of GDS between the AACD group and subjects with AD (p<0.05).
This study suggested that BDNF might be involved in the pathophysiology of cognitive decline in elderly people.
本研究的主要目的是探讨血清脑源性神经营养因子（BDNF）水平在 65 岁以上韩国痴呆与非痴呆老年人之间的差异。
本研究纳入了 171 名 65 岁以上的个体。采用简易精神状态检查韩国版（MMSE-KC）对认知障碍进行筛查。132 名受试者的 MMSE-KC 评分低于平均 MMSE-KC 评分的 1.5 个标准差（SD），对这些受试者采用阿尔茨海默病协作研究-韩国版（CERAD-K）和老年抑郁量表（GDS）进行评估。采用临床痴呆评定量表（CDRS）和精神障碍诊断与统计手册第四版（DSM-IV）诊断标准进行进一步评估。CDRS 评分≥1 分的受试者被归类为阿尔茨海默病（AD），CDRS 评分 0.5 分的受试者被归类为轻度认知障碍（MCI），CDRS 评分 0 分的受试者被归类为与年龄相关的认知衰退（AACD）。采用酶联免疫吸附试验（ELISA）法分析血清 BDNF 水平。
与健康对照组相比，MCI 和 AD 受试者的血清 BDNF 水平显著降低（p<0.01）。总 MMSE-KC 评分与血清 BDNF 水平呈显著正相关（r=0.295；p<0.01）。然而，MMSE-KC 严重程度与总 GDS 评分之间无显著相关性。AACD 组与 AD 组之间的 GDS 总分存在显著差异（p<0.05）。
本研究提示 BDNF 可能参与了老年人认知下降的病理生理过程。
