V. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
Pirogov Russian National Research Medical University, Moscow, Russia.
Bull Exp Biol Med. 2024 Aug;177(4):517-527. doi: 10.1007/s10517-024-06218-5. Epub 2024 Sep 12.
The review considers the use of exogenous neurotrophic factors in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and others. This group of diseases is associated with the death of neurons and dysfunction of the nervous tissue. Currently, there is no effective therapy for neurodegenerative diseases, and their treatment remains a serious problem of modern medicine. A promising strategy is the use of exogenous neurotrophic factors. Targeted delivery of these factors to the nervous tissue can improve survival of neurons during the development of neurodegenerative processes and ensure neuroplasticity. There are methods of direct injection of neurotrophic factors into the nervous tissue, delivery using viral vectors, as well as the use of gene cell products. The effectiveness of these approaches has been studied in numerous experimental works and in a number of clinical trials. Further research in this area could provide the basis for the creation of an alternative treatment for neurodegenerative diseases.
该综述探讨了外源性神经生长因子在治疗神经退行性疾病（如阿尔茨海默病、帕金森病、多发性硬化症等）中的应用。这组疾病与神经元死亡和神经组织功能障碍有关。目前，对于神经退行性疾病尚无有效的治疗方法，其治疗仍然是现代医学的一个严重问题。一种有前途的策略是使用外源性神经生长因子。将这些因子靶向递送至神经组织可以改善神经退行性过程中神经元的存活并确保神经可塑性。有将神经生长因子直接注射到神经组织中的方法，使用病毒载体进行递送，以及使用基因细胞产物的方法。这些方法的有效性已在许多实验工作和一些临床试验中得到研究。该领域的进一步研究可为神经退行性疾病的替代治疗方法提供基础。
