Santa Casa de Misericórdia de São Paulo/HSLG, São Paulo, SP, Brazil.
Braz J Infect Dis. 2009 Apr;13(2):104-6.
Pneumococcal (Pnc) carriage is associated with pneumococcal diseases. Breast feeding and maternal vaccination may be a useful approach to prevent pneumococcal infection in young infants. We examined the risk of Pnc carriage by infants at six months of age after pneumococcal polysaccharide vaccination of pregnant women. We selected 139 pregnant woman. The woman were randomly allocated to receive 23-valent polysaccharide vaccines during pregnancy (Group 1) after pregnancy (Group 2) or not receive any vaccine (Group 3). Nasopharyngeal swabs were collected from the infants at three and six months of age. The infants were evaluated monthly during the first six months. We included 47 mothers in Group 1, 45 mothers in Group 2 and 47 mothers in Group 3. Forty-seven percent of the babies were exclusively breast fed until six months, 26% received both breast feeding and artificial feeding and 13% received only artificial feeding. Among those patients, 26% were colonized by Pnc at six months (12 from Group 1, 13 from Group 2, and 12 from Group 3). There was no significant difference in colonization between the three groups. Thirty percent of the children were colonized by a non-susceptible strain. We concluded that young infants (three months old) are already susceptible to pneumococcal carriage. Vaccination during pregnancy with a polysaccharide vaccine did not decrease Pnc colonization.
肺炎球菌（Pnc）携带与肺炎球菌病有关。母乳喂养和母亲疫苗接种可能是预防婴幼儿肺炎球菌感染的有效方法。我们研究了孕妇接种肺炎球菌多糖疫苗后 6 个月龄婴儿携带 Pnc 的风险。我们选择了 139 名孕妇。这些妇女被随机分配在怀孕期间（第 1 组）、产后（第 2 组）或不接受任何疫苗接种（第 3 组）接受 23 价多糖疫苗。在婴儿 3 个月和 6 个月时从鼻咽部采集拭子。在头 6 个月期间，每月对婴儿进行评估。我们纳入了第 1 组的 47 名母亲、第 2 组的 45 名母亲和第 3 组的 47 名母亲。47%的婴儿在 6 个月前完全母乳喂养，26%的婴儿接受母乳喂养和人工喂养，13%的婴儿仅接受人工喂养。在这些患者中，26%的婴儿在 6 个月时被 Pnc 定植（第 1 组 12 例，第 2 组 13 例，第 3 组 12 例）。三组之间定植无显著差异。30%的儿童被非敏感菌株定植。我们得出结论，3 个月大的婴儿已经容易发生肺炎球菌定植。怀孕期间接种多糖疫苗不能降低 Pnc 的定植。
