Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Clin Rheumatol. 2010 Jul;29(7):799-801. doi: 10.1007/s10067-010-1390-x. Epub 2010 Feb 7.
Autoimmune hepatitis (AIH) is a chronic hepatitis of unknown etiology characterized by continuing hepatocellular necrosis and inflammation that afflicts 100,000 to 200,000 persons in the United States. It is a rare manifestation of systemic sclerosis. Only about nine reports of this association have been previously reported in the literature. Importantly, all cases had the limited clinical form of systemic. The authors describe herein the first report of a patient with diffuse systemic sclerosis who was diagnosed with AIH with positive antimitochondrial antibody and had an excellent response to immunosuppressive drugs. We also briefly review the literature regarding this issue.
自身免疫性肝炎（AIH）是一种病因不明的慢性肝炎，其特征为持续的肝细胞坏死和炎症，影响美国 10 万至 20 万人。它是系统性硬皮病的罕见表现。以前文献中仅报道过约 9 例这种关联的病例。重要的是，所有病例均具有系统性的局限性临床表现。作者在此描述了首例诊断为 AIH 的弥漫性系统性硬皮病患者，该患者的抗线粒体抗体呈阳性，对免疫抑制剂治疗有极好的反应。我们还简要回顾了该问题的文献。
