Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, USA.
Ann Hepatol. 2012 Jul-Aug;11(4):559-63.
Peripheral blood eosinophilia has been described in a broad variety of allergic, infectious, neoplastic and autoimmune diseases. To the best of our knowledge blood eosinophilia has never previously been reported in association with isolated autoimmune hepatitis (AIH) in the absence of other autoimmune conditions. Herein we report an interesting case of an 18 year old man who presented to our hospital with an acute autoimmune hepatitis diagnosed on the basis of clinical features, serology and histopathology. He was noted to have a moderate peripheral eosinophilia at diagnosis which resolved within days of initiation of corticosteroids for treatment of the AIH. Given the absence of other systemic conditions or drugs which may have produced the eosinophilia and its rapid resolution with treatment of the underlying liver disease, we wished to highlight this rather novel presentation of AIH.
外周血嗜酸性粒细胞增多可见于多种过敏性、感染性、肿瘤性和自身免疫性疾病。据我们所知，在没有其他自身免疫性疾病的情况下，血液嗜酸性粒细胞增多以前从未与孤立性自身免疫性肝炎（AIH）相关报道过。在此，我们报告了一例有趣的病例，一名 18 岁男性因急性自身免疫性肝炎就诊于我院，该诊断基于临床特征、血清学和组织病理学。他在诊断时被发现外周血嗜酸性粒细胞中度增多，在开始用皮质类固醇治疗 AIH 后几天内就得到了缓解。鉴于没有其他可能导致嗜酸性粒细胞增多的系统性疾病或药物，并且嗜酸性粒细胞增多在治疗基础肝病后迅速缓解，我们希望强调这种相当新颖的 AIH 表现。
