Jiménez-Encarnación Esther, Ríos Grissel, Muñoz-Mirabal Angel, Vilá Luis M
Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.
BMJ Case Rep. 2012 Dec 19;2012:bcr2012006907. doi: 10.1136/bcr-2012-006907.
Euforia, a supplement containing a variety of natural ingredients, is widely used as an antioxidant and anti-inflammatory formula. It is not approved by the US Food and Drug Administration and its side effects are unknown. We report a 45-year-old woman with limited systemic sclerosis who presented with jaundice and marked elevation of serum transaminases. One month before, she started taking Euforia juice. A liver biopsy disclosed submassive hepatocellular necrosis with histopathological changes consistent with toxic hepatitis. The patient's symptoms resolved with cessation of Euforia. Six months later, she persisted with abnormal liver function tests, but these resolved 18 months after discontinuation of Euforia. The mechanism by which Euforia causes liver injury is unknown. Some ingredients contained in this supplement (green tea, Aloe vera, noni and goji) are linked to hepatic injury. To our knowledge, this is the first report of hepatotoxicity associated with Euforia.
Euforia是一种含有多种天然成分的补充剂，被广泛用作抗氧化和抗炎配方。它未获得美国食品药品监督管理局的批准，其副作用也未知。我们报告了一名45岁的局限性系统性硬化症女性患者，她出现黄疸和血清转氨酶显著升高。一个月前，她开始饮用Euforia果汁。肝脏活检显示亚大块肝细胞坏死，组织病理学变化与中毒性肝炎一致。停用Euforia后，患者症状缓解。六个月后，她的肝功能检查仍异常，但停用Euforia 18个月后这些异常情况得到缓解。Euforia导致肝损伤的机制尚不清楚。这种补充剂中的一些成分（绿茶、芦荟、诺丽果和枸杞）与肝损伤有关。据我们所知，这是首例与Euforia相关的肝毒性报告。
