Ishikawa Takamichi, Iwashima Satoru, Ohzeki Takehiko
Department of Pediatrics, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Japan.
Pediatr Cardiol. 2010 Jul;31(5):707-10. doi: 10.1007/s00246-010-9651-7. Epub 2010 Feb 7.
This report presents the case of an 8-year-old male with biventricular hypertrophic obstructive cardiomyopathy who achieved a successful reduction of the pressure gradients by treatment with cibenzoline. Ultrasound echocardiography showed marked intraventricular septal hypertrophy and left midventricular and right ventricular outflow obstructions. A cardiac catheterization revealed left midventricular and right outflow obstructions associated with pressure gradients of 100 and 35 mmHg, respectively. An intravenous injection of 28 mg (1.4 mg/kg) cibenzoline immediately improved the biventricular pressure gradients. Therefore, oral cibenzoline treatment was initiated, the dose was increased to 150 mg/day, and both pressure gradients remained low, without any complications at the time of discharge, 4 months later.
本报告介绍了一名8岁男性双心室肥厚型梗阻性心肌病患者，通过西苯唑啉治疗成功降低了压力阶差。超声心动图显示明显的室间隔肥厚以及左心室中部和右心室流出道梗阻。心导管检查显示左心室中部和右心室流出道梗阻，压力阶差分别为100 mmHg和35 mmHg。静脉注射28 mg（1.4 mg/kg）西苯唑啉后，双心室压力阶差立即得到改善。因此，开始口服西苯唑啉治疗，剂量增加至150 mg/天，4个月后出院时，两个压力阶差均保持较低水平，且无任何并发症。
