Institute of Microbiology, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovak Republic.
Folia Microbiol (Praha). 2009 Nov;54(6):563-5. doi: 10.1007/s12223-009-0083-9. Epub 2010 Feb 7.
Two cases are presented of severe pneumococcal infections in infants caused by serotype 14 Streptococcus pneumoniae. The first case--meningitis--caused by S. pneumoniae (pneumococcus) with low-level penicillin susceptibility has developed from acute otitis media and resulted in fatal outcome. The second one--an immunocompromised child presenting recurrent otitis and chronic mastoiditis--developed into pneumococcal pneumonia. Both cases demonstrate the extreme importance of a relevant initial treatment of localized pneumococcal infections, preventing the development of generalized infection. Amoxicillin (an oral treatment option in both upper and lower respiratory tract infections caused also by Pneumococcus strains with low-level penicillin susceptibility due to its beneficial pharmacokinetics and pharmacodynamics) was not used in either case.
现报告两例由血清型 14 肺炎链球菌引起的婴幼儿重症肺炎球菌感染。第一个病例——脑膜炎，由青霉素低水平敏感性的肺炎链球菌（肺炎球菌）引起，源于急性中耳炎，导致了致命的结果。第二个病例——免疫功能低下的儿童反复发作中耳炎和慢性乳突炎，发展为肺炎球菌肺炎。这两个病例都表明了及时治疗局部肺炎球菌感染的重要性，以防止全身性感染的发生。在这两种情况下都没有使用阿莫西林（一种口服治疗选择，也可用于治疗由青霉素低水平敏感性的肺炎链球菌菌株引起的上呼吸道和下呼吸道感染，因为它具有良好的药代动力学和药效学）。
