State Key Laboratory of Nuclear Physics and Technology, Center for Applied Physics and Technology, Peking University, Beijing, 100871, P.R.China.
Chemphyschem. 2010 Mar 15;11(4):859-64. doi: 10.1002/cphc.200900989.
Herein we demonstrate a fully abiotic smart single-nanopore device that rectifies ionic current in response to the temperature. The temperature-responsive nanopore ionic rectifier can be switched between a rectifying state below 34 degrees C and a non-rectifying state above 38 degrees C actuated by the phase transition of the poly(N-isopropylacrylamide) [PNIPAM] brushes. On the rectifying state, the rectifying efficiency can be enhanced by the dehydration of the attached PNIPAM brushes below the LCST. When the PNIPAM brushes have sufficiently collapsed, the nanopore switches to the non-rectifying state. The concept of the temperature-responsive current rectification in chemically-modified nanopores paves a new way for controlling the preferential direction of the ion transport in nanofluidics by modulating the temperature, which has the potential to build novel nanomachines with smart fluidic communication functions for future lab-on-chip devices.
在此，我们展示了一种完全非生物的智能单纳米孔器件，它可以响应温度对离子电流进行整流。温度响应纳米孔离子整流器可以在低于 34 摄氏度的整流状态和高于 38 摄氏度的非整流状态之间切换，由聚（N-异丙基丙烯酰胺）[PNIPAM]刷的相转变驱动。在整流状态下，通过低于 LCST 的附着 PNIPAM 刷的去水作用可以增强整流效率。当 PNIPAM 刷充分坍塌时，纳米孔切换到非整流状态。化学修饰的纳米孔中温度响应的电流整流的概念为通过调节温度来控制纳米流道中离子输运的优先方向开辟了一条新途径，这有可能为未来的片上实验室设备构建具有智能流体通信功能的新型纳米机器。
