Garganeeva N P, Kartashova I G, Semke V Ia
Ter Arkh. 2009;81(11):44-8.
to study clinicoendoscopic and psychopathological relationships and the course of peptic ulcer (PU) in patients with neurotic and affective disorders and to evaluate the efficiency of psychopharmacotherapy, by applying a comprehensive approach to the treatment of comorbidies.
The study covered 245 patients aged 43.3 +/- 8.8 years from the Department of Borderline Conditions who had been diagnosed as having duodenal PU and gastric PU with a prevalence of stress-associated neurotic disorders, as well as affective and other ones. Clinical psychopathological and experimental psychological tests and rating psychometric scales were used to evaluate the patients' mental status. Somatic diseases were verified by endoscopic, morphological, and ultrasound diagnostic techniques.
Multivariate analysis has revealed a relationship of the phase of an ulcerative process and age to the first manifestations of psychopathology, its duration, and gender. Assessment of psychopharmacotherapy in patients with PU has shown the high efficacy of the antidepressant of coaxil in the treatment of the comorbidity.
The polymorphism of psychopathological disorders and their trend are determined by the clinical changes in the course of an ulcerative or erosive process. The inclusion of coaxil into the combined treatment regimen for PU in patients with neurotic and affective disorders is expedient and pathogenetically founded at all stages of a follow-up.
通过采用综合方法治疗合并症，研究神经症和情感障碍患者的临床内镜与心理病理关系及消化性溃疡（PU）病程，并评估心理药物治疗的效果。
研究涵盖了来自边缘性疾病科的245名年龄在43.3±8.8岁的患者，这些患者被诊断患有十二指肠PU和胃溃疡，伴有应激相关神经症以及情感和其他疾病。采用临床心理病理和实验心理学测试以及心理测量评定量表来评估患者的精神状态。通过内镜、形态学和超声诊断技术来确诊躯体疾病。
多变量分析揭示了溃疡进程阶段和年龄与心理病理学的首发表现、持续时间及性别之间的关系。对PU患者心理药物治疗的评估显示，可塞风抗抑郁药在治疗合并症方面具有高效性。
心理病理障碍的多态性及其趋势由溃疡性或糜烂性进程中的临床变化所决定。在神经症和情感障碍患者的PU联合治疗方案中加入可塞风在随访的各个阶段都是适宜且有发病学依据的。
