Perry Michelle L, Andrzejewski Matthew E, Bushek Susan M, Baldo Brian A
Molecular and Cellular Pharmacology and Department of Psychiatry, University of Wisconsin.
Waisman Center, University of Wisconsin.
Behav Neurosci. 2010 Feb;124(1):44-54. doi: 10.1037/a0018283.
Previous work has implicated the cholinergic system in modulating feeding behavior; however, its specific function remains unclear. This work aims to characterize potential dissociations between the central cholinergic modulation of the incentive properties of food and food-associated cues, and consummatory behaviors. Three separate experiments demonstrated that intra-accumbens infusion of the muscarinic antagonist scopolamine 3 hr before the testing session significantly decreased food intake. General motor activity in anticipation of food was not diminished. Experiments also showed that scopolamine did not impair operant responding for a food-associated conditioned reinforcer (CR), nor was d-amphetamine potentiation of CR responding altered by scopolamine pretreatment. This study contributes to the growing evidence that goal-seeking behaviors are mediated by a set of neural processes distinct from those governing food reward.
先前的研究表明胆碱能系统参与调节进食行为；然而，其具体功能仍不清楚。这项研究旨在明确食物激励特性的中枢胆碱能调节与食物相关线索及进食行为之间潜在的分离情况。三个独立实验表明，在测试前3小时向伏隔核内注射毒蕈碱拮抗剂东莨菪碱可显著减少食物摄入量。预期食物时的一般运动活动并未减弱。实验还表明，东莨菪碱不会损害对与食物相关的条件强化物（CR）的操作性反应，毒蕈碱预处理也不会改变d-苯丙胺对CR反应的增强作用。这项研究为越来越多的证据提供了补充，即追求目标的行为是由一组与控制食物奖赏的神经过程不同的神经过程介导的。
