Perry Michelle L, Baldo Brian A, Andrzejewski Matthew E, Kelley Ann E
Molecular and Cellular Pharmacology, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53719, USA.
Behav Brain Res. 2009 Jan 30;197(1):225-9. doi: 10.1016/j.bbr.2008.08.002. Epub 2008 Aug 12.
Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 microg/0.5 microl), markedly reduced fat intake elicited by intra-Acb treatment of the mu-opioid receptor agonist, DAMGO, with 30 min and 4h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system.
向伏隔核(Acb)内注射胆碱能毒蕈碱拮抗剂东莨菪碱(10微克/0.5微升),在预处理间隔为30分钟和4小时的情况下,可显著降低由向Acb内注射μ-阿片受体激动剂DAMGO所引发的脂肪摄入量。向Acb内注射东莨菪碱也会减少饥饿大鼠的食物摄入量,但不会减少缺水大鼠的饮水量。因此,对Acb毒蕈碱的操控对进食表现出一定的特异性,可能是通过与纹状体阿片系统的相互作用实现的。