Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Leuk Lymphoma. 2010 Mar;51(3):469-74. doi: 10.3109/10428190903556394.
Autoimmune cytopenias are typical paraneoplastic phenomena in malignant lymphomas. We assessed the occurrence, clinical, and laboratory features as well as the response to treatment of autoimmune hemolytic anemia, autoimmune thrombocytopenia, and neutropenia in published cases of Hodgkin lymphomas (HL). We identified 34 cases of an association between HL and autoimmune hemolytic anemia and 48 cases of an association of autoimmune thrombocytopenia (AITP) and HL. The autoimmune cytopenias (AIC) may occur prior to, concurrent with, at the time of recurrence of lymphoma or in complete remission after treatment. Almost all autoimmune hemolytic anemias were caused by warm antibodies. Patients with HL with AIC are more commonly males and are more likely to have mixed cellularity (MC) HL. HL is the only lymphoma which may be associated with autoimmune neutropenia. In contrast to AIC in diffuse large B-cell lymphoma (DLBCL), early stage is less common in patients with HL with AIC. AIC in HL respond better to antilymphoma treatment than to steroids, with the exception of post-treatment AITP in CR of HL which responds easily and durably to steroids.
自身免疫性细胞减少症是恶性淋巴瘤中典型的副肿瘤现象。我们评估了已发表的霍奇金淋巴瘤 (HL) 病例中自身免疫性溶血性贫血、自身免疫性血小板减少症和中性粒细胞减少症的发生、临床和实验室特征以及对治疗的反应。我们确定了 34 例 HL 与自身免疫性溶血性贫血之间的关联，以及 48 例自身免疫性血小板减少症 (AITP) 与 HL 之间的关联。自身免疫性细胞减少症 (AIC) 可发生在淋巴瘤之前、同时、复发时或治疗后完全缓解时。几乎所有自身免疫性溶血性贫血都是由温抗体引起的。患有 AIC 的 HL 患者更常见于男性，并且更可能患有混合细胞性 (MC) HL。HL 是唯一可能与自身免疫性中性粒细胞减少症相关的淋巴瘤。与弥漫性大 B 细胞淋巴瘤 (DLBCL) 中的 AIC 相比，患有 AIC 的 HL 患者中早期阶段较少。与类固醇相比，AIC 在 HL 中的抗淋巴瘤治疗反应更好，除了 HL 在 CR 中的类固醇治疗后 AITP 反应迅速且持久。
