Foster S, Hawkins E, Hanson C G, Shearer W
Department of Pathology, Baylor College of Medicine 77030.
Pediatr Pathol. 1991 Jan-Feb;11(1):63-74. doi: 10.3109/15513819109064742.
Clinical and nephropathologic findings in autopsy material from 7 children with acquired immune deficiency syndrome (AIDS), 13 with severe combined immune deficiency (SCID), and 6 with a variety of other congenital immune deficiencies were reviewed in an effort to understand better the pathophysiology of the AIDS-related nephropathy. Non-HIV viral infection seemed to be associated with the development of the pathologic changes considered to be components of the AIDS-related nephropathy, and these changes, including focal segmental glomerulosclerosis (FSGS) and tubular epithelial cell injury and ectasia, were not limited to the kidneys of children with AIDS but were present in many of the congenital immune deficiencies. Of the 5 children with congenital AIDS, only the 3 who survived longer than a year developed AIDS-related nephropathy, whereas the two children with transfusion-acquired AIDS did not develop renal disease despite surviving for several years after initial infection.
回顾了7名获得性免疫缺陷综合征（AIDS）患儿、13名严重联合免疫缺陷（SCID）患儿以及6名患有各种其他先天性免疫缺陷患儿尸检材料中的临床和肾脏病理结果，以便更好地了解艾滋病相关肾病的病理生理学。非HIV病毒感染似乎与被认为是艾滋病相关肾病组成部分的病理变化的发展有关，这些变化包括局灶节段性肾小球硬化（FSGS）以及肾小管上皮细胞损伤和扩张，并不局限于艾滋病患儿的肾脏，在许多先天性免疫缺陷患儿中也存在。在5名先天性艾滋病患儿中，只有3名存活超过一年的患儿发生了艾滋病相关肾病，而两名输血获得性艾滋病患儿尽管在初次感染后存活了数年，但并未发生肾脏疾病。
