Ariel I, Singer D B
Department of Pathology, Brown University Program in Medicine, Providence, Rhode Island.
Pediatr Pathol. 1991 Jan-Feb;11(1):75-83. doi: 10.3109/15513819109064743.
During a 14-year period Streptococcus viridans was isolated at autopsy from 18 neonates or stillborn fetuses delivered in midgestation (18-28 weeks) at Women & Infants' Hospital in Providence, Rhode Island. Evidence of swallowed and/or aspirated, infected amniotic fluid by the fetus was found in 16 of 18 cases along with chorioamnionitis and funisitis. Of the 18 cases, maternal infection was documented in 6 cases; delivery was preceded by spontaneous rupture of membranes in 9 cases and vaginal bleeding in 7 cases. Poor maternal obstetric history was indicated by only 12 living children from 42 total pregnancies in the 12 multigravidas in the study. It is concluded that S. viridans may have a significant role in the pathogenesis of second trimester amniotic fluid infections with abortions and fetal and neonatal sepsis.
在14年期间，从罗德岛普罗维登斯妇女与婴儿医院妊娠中期（18 - 28周）分娩的18例新生儿或死产胎儿的尸检中分离出草绿色链球菌。18例中有16例发现胎儿有吞咽和/或吸入感染羊水的证据，同时伴有绒毛膜羊膜炎和脐带炎。18例中，6例有母体感染记录；9例在分娩前胎膜自发破裂，7例有阴道出血。该研究中的12名经产妇共有42次妊娠，仅12名存活子女，提示产妇产科病史不佳。结论是草绿色链球菌可能在孕中期羊水感染伴流产及胎儿和新生儿败血症的发病机制中起重要作用。
