Singer D B, Campognone P
Pediatr Pathol. 1986;5(3-4):271-6. doi: 10.3109/15513818609068854.
In a series of 32 fetuses and neonates studied at autopsy at Women and Infants Hospital, group B streptococcus (GBS) was isolated from the right atrial blood or from the lung. Eleven or 34% (5 stillborn fetuses and 6 liveborn infants) were delivered in midgestation, between 18 and 28 weeks, and all weighed less than 1000 g. Maternal clinical features in GBS infection during midgestation included vaginal hemorrhage in 4 and premature rupture of membranes in 8. The high rate of fetal death associated with this infection in midgestation (45%) bears emphasizing. Reproductive loss among mothers with previous pregnancies seems to be a risk factor for subsequent perinatal loss due to GBS. Of 17 pregnancies among these 11 mothers, only 3 resulted in living children. Colonized mothers with GBS are usually treated late in the third trimester, if at all. This study indicates that attention must be directed to midgestation, at least among the high-risk group.
在妇女和婴儿医院对32例胎儿和新生儿进行尸检研究时，从右心房血液或肺部分离出B族链球菌（GBS）。11例（占34%，包括5例死产胎儿和6例活产婴儿）在妊娠中期（18至28周）分娩，且体重均不足1000克。妊娠中期GBS感染的母亲临床特征包括4例阴道出血和8例胎膜早破。这种妊娠中期感染相关的高胎儿死亡率（45%）值得强调。既往有过妊娠的母亲中生殖损失似乎是随后因GBS导致围产期损失的一个危险因素。在这11位母亲的17次妊娠中，只有3次分娩出存活儿童。携带GBS的母亲通常在妊娠晚期才进行治疗，甚至根本未治疗。本研究表明，至少在高危人群中，必须关注妊娠中期。
