Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Mult Scler. 2010 Feb;16(2):252-4. doi: 10.1177/1352458509355070.
Optic neuritis (ON) patients can be divided into two groups based on the presence or absence of asymptomatic demyelinating lesions (ADLs) on brain MRI. The presence of ADLs is associated with an increased risk of progression to clinically definite multiple sclerosis (CDMS). The clinical data and brain MRI of 110 patients with acute unilateral ON were analyzed. Patients with ADLs had a significantly higher incidence of ON in spring months as compared with patients with no ADLs (p = 0.0024). Increased incidence of ON in spring months was seen in patients with ADLs whether or not they were diagnosed with CDMS on follow-up.
视神经炎（ON）患者可根据脑部磁共振成像（MRI）上是否存在无症状脱髓鞘病变（ADL）分为两组。ADL 的存在与向临床确诊多发性硬化症（CDMS）进展的风险增加相关。分析了 110 例急性单侧 ON 患者的临床数据和脑部 MRI。与无 ADL 的患者相比，有 ADL 的患者春季发生 ON 的发生率明显更高（p = 0.0024）。无论在随访中是否被诊断为 CDMS，有 ADL 的患者在春季发生 ON 的发生率均增加。
