斯特普®含片可减少气管插管后的咽喉痛和声音嘶哑。

Strepsils® tablets reduce sore throat and hoarseness after tracheal intubation.

机构信息

Department of Anesthesiology, Sadi Hospital, Khodaverdi Alley, Sadi Blv, Isfahan, Iran.

出版信息

Anesth Analg. 2010 Oct;111(4):892-4. doi: 10.1213/ANE.0b013e3181d00c60. Epub 2010 Feb 8.

DOI:10.1213/ANE.0b013e3181d00c60

PMID:20142339

Abstract

BACKGROUND

Amyl-m-cresol (Strepsils®) has been successfully used in the prophylaxis and treatment of oral inflammations, but its effects on postintubation sore throat and hoarseness are unknown. We conducted this study to evaluate the effects of Strepsils in reducing postintubation sore throat and hoarseness.

METHODS

One hundred fifty patients, ASA physical status I to II, scheduled to undergo general anesthesia and elective orthopedic or gynecologic surgery were enrolled. Participants were randomly allocated to receive either Strepsils or identical-looking placebo tablets immediately before arrival to the operating room. The incidence and severity of postoperative sore throat and hoarseness were evaluated immediately and 24 hours after surgery.

RESULTS

The incidence of early postoperative sore throat was 13.7% and 33.3% and hoarseness was 12.3% and 26.4% in the Strepsils and placebo groups, respectively (P < 0.05). One day after surgery, the incidence of sore throat decreased to 6.8% and 18.1% in the Strepsils and control groups, respectively. The incidence of hoarseness 1 day after the operation decreased to 8.2% in the Strepsils group and 19.4% in the placebo group, but the difference remained statistically significant (P < 0.05).

CONCLUSION

Perioperative use of Strepsils tablets reduces postoperative sore throat and hoarseness of voice.

摘要

背景

氨来呫诺（Strepsils®）已成功用于预防和治疗口腔炎症，但它对插管后咽喉痛和声音嘶哑的影响尚不清楚。我们进行这项研究是为了评估 Strepsils 减少插管后咽喉痛和声音嘶哑的效果。

方法

150 名 ASA 身体状况 I 至 II 级的患者，计划接受全身麻醉和择期骨科或妇科手术，被纳入研究。参与者被随机分配接受 Strepsils 或外观相同的安慰剂片，在到达手术室之前立即服用。术后即刻和 24 小时评估术后咽喉痛和声音嘶哑的发生率和严重程度。

结果

Strepsils 组和安慰剂组术后早期咽喉痛的发生率分别为 13.7%和 33.3%，声音嘶哑的发生率分别为 12.3%和 26.4%（P<0.05）。术后 1 天，Strepsils 组和对照组咽喉痛的发生率分别降至 6.8%和 18.1%。术后 1 天声音嘶哑的发生率降至 Strepsils 组的 8.2%和安慰剂组的 19.4%，但差异仍有统计学意义（P<0.05）。